L1J3H6_GUITC protein (Guillardia theta) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

L1J3H6_GUITC

Uncharacterized protein. (171 aa)

Predicted Functional Partners:

L1I7B2_GUITC

0.619

L1I8E8_GUITC

0.619

L1I9U3_GUITC

0.615

L1IA66_GUITC

0.615

L1IEA0_GUITC

0.615

L1II80_GUITC

0.615

UBQ_RPS30e

0.581

L1IVV8_GUITC

0.534

L1JUB2_GUITC

0.523

L1INU9_GUITC

0.500

Your Current Organism:

Guillardia theta

NCBI taxonomy Id: 905079
Other names: G. theta CCMP2712, Guillardia theta CCMP2712

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
L1I7B2_GUITC	L1I8E8_GUITC	L1I7B2	L1I8E8	Zink finger-like fusion protein.	Ubiquitin/60s ribosomal protein L40 fusion protein.	0.902
L1I7B2_GUITC	L1I9U3_GUITC	L1I7B2	L1I9U3	Zink finger-like fusion protein.	HECT domain-containing protein.	0.705
L1I7B2_GUITC	L1IA66_GUITC	L1I7B2	L1IA66	Zink finger-like fusion protein.	Uncharacterized protein.	0.705
L1I7B2_GUITC	L1IEA0_GUITC	L1I7B2	L1IEA0	Zink finger-like fusion protein.	HECT domain-containing protein.	0.705
L1I7B2_GUITC	L1II80_GUITC	L1I7B2	L1II80	Zink finger-like fusion protein.	HECT domain-containing protein.	0.705
L1I7B2_GUITC	L1INU9_GUITC	L1I7B2	L1INU9	Zink finger-like fusion protein.	Ubiquitin-superoxide dismutase fusion protein.	0.934
L1I7B2_GUITC	L1IVV8_GUITC	L1I7B2	L1IVV8	Zink finger-like fusion protein.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.584
L1I7B2_GUITC	L1J3H6_GUITC	L1I7B2	L1J3H6	Zink finger-like fusion protein.	Uncharacterized protein.	0.619
L1I7B2_GUITC	L1JUB2_GUITC	L1I7B2	L1JUB2	Zink finger-like fusion protein.	Uncharacterized protein.	0.958
L1I7B2_GUITC	UBQ_RPS30e	L1I7B2	L1JWJ6	Zink finger-like fusion protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.999
L1I8E8_GUITC	L1I7B2_GUITC	L1I8E8	L1I7B2	Ubiquitin/60s ribosomal protein L40 fusion protein.	Zink finger-like fusion protein.	0.902
L1I8E8_GUITC	L1I9U3_GUITC	L1I8E8	L1I9U3	Ubiquitin/60s ribosomal protein L40 fusion protein.	HECT domain-containing protein.	0.705
L1I8E8_GUITC	L1IA66_GUITC	L1I8E8	L1IA66	Ubiquitin/60s ribosomal protein L40 fusion protein.	Uncharacterized protein.	0.705
L1I8E8_GUITC	L1IEA0_GUITC	L1I8E8	L1IEA0	Ubiquitin/60s ribosomal protein L40 fusion protein.	HECT domain-containing protein.	0.705
L1I8E8_GUITC	L1II80_GUITC	L1I8E8	L1II80	Ubiquitin/60s ribosomal protein L40 fusion protein.	HECT domain-containing protein.	0.705
L1I8E8_GUITC	L1INU9_GUITC	L1I8E8	L1INU9	Ubiquitin/60s ribosomal protein L40 fusion protein.	Ubiquitin-superoxide dismutase fusion protein.	0.934
L1I8E8_GUITC	L1IVV8_GUITC	L1I8E8	L1IVV8	Ubiquitin/60s ribosomal protein L40 fusion protein.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.584
L1I8E8_GUITC	L1J3H6_GUITC	L1I8E8	L1J3H6	Ubiquitin/60s ribosomal protein L40 fusion protein.	Uncharacterized protein.	0.619
L1I8E8_GUITC	L1JUB2_GUITC	L1I8E8	L1JUB2	Ubiquitin/60s ribosomal protein L40 fusion protein.	Uncharacterized protein.	0.958
L1I8E8_GUITC	UBQ_RPS30e	L1I8E8	L1JWJ6	Ubiquitin/60s ribosomal protein L40 fusion protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.999

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Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.919

expected number of edges:

10

PPI enrichment p-value:

5.16e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006696

Ergosterol biosynthetic process

8 of 23

2.06

4.77

4.99e-12

GO:0008299

Isoprenoid biosynthetic process

6 of 14

2.15

4.17

9.02e-10

GO:0019287

Isopentenyl diphosphate biosynthetic process, mevalonate pathway

4 of 4

2.52

3.35

4.07e-07

GO:0006721

Terpenoid metabolic process

4 of 7

2.28

2.94

1.63e-06

GO:0045338

Farnesyl diphosphate metabolic process

3 of 6

2.22

2.0

0.00014

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4427

Ergosterol metabolic process

7 of 17

2.13

4.61

4.79e-11

CL:4451

Isopentenyl diphosphate biosynthetic process, mevalonate pathway

4 of 5

2.42

3.2

6.74e-07

CL:4429

Steroid biosynthesis

3 of 11

1.95

1.57

0.00075

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00900

Terpenoid backbone biosynthesis

5 of 22

1.88

2.68

8.45e-07

map00100

Steroid biosynthesis

3 of 14

1.85

1.57

0.00057

map01110

Biosynthesis of secondary metabolites

8 of 204

1.11

1.33

1.02e-06

map01100

Metabolic pathways

8 of 639

0.62

0.47

0.0029

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-191273

Cholesterol biosynthesis

6 of 18

2.04

3.55

1.45e-08

MAP-8957322

Metabolism of steroids

6 of 37

1.73

2.59

3.22e-07

MAP-556833

Metabolism of lipids

7 of 130

1.25

1.48

6.84e-06

MAP-1430728

Metabolism

7 of 484

0.68

0.42

0.0303

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0753

Steroid metabolism

3 of 6

2.22

1.82

0.00033

KW-0752

Steroid biosynthesis

3 of 6

2.22

1.82

0.00033

KW-0756

Sterol biosynthesis

2 of 5

2.12

1.15

0.0068

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00288

GHMP kinases N terminal domain

3 of 3

2.52

2.04

0.00016

PF08544

GHMP kinases C terminal

2 of 2

2.52

1.1

0.0097

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006204

GHMP kinase N-terminal domain

3 of 3

2.52

1.75

0.00059

IPR014721

Ribosomal protein S5 domain 2-type fold, subgroup

3 of 17

1.77

0.91

0.0163

IPR036554

GHMP kinase, C-terminal domain superfamily

2 of 2

2.52

0.89

0.0238

IPR013750

GHMP kinase, C-terminal domain

2 of 2

2.52

0.89

0.0238

IPR020568

Ribosomal protein S5 domain 2-type fold

3 of 24

1.62

0.8

0.0238

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