L1JB10_GUITC protein (Guillardia theta) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

L1JB10_GUITC

Thioredoxin domain-containing protein. (185 aa)

Predicted Functional Partners:

TrxM

0.672

L1IGW3_GUITC

0.545

L1JCJ9_GUITC

0.545

L1JD81_GUITC

0.545

L1JSH8_GUITC

0.545

L1IM58_GUITC

0.517

L1IWP8_GUITC

0.455

L1IDF8_GUITC

0.450

L1JVY9_GUITC

0.421

Your Current Organism:

Guillardia theta

NCBI taxonomy Id: 905079
Other names: G. theta CCMP2712, Guillardia theta CCMP2712

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
L1IDF8_GUITC	L1IGW3_GUITC	L1IDF8	L1IGW3	Uncharacterized protein.	Heat shock protein 70; Belongs to the heat shock protein 70 family.	0.545
L1IDF8_GUITC	L1JB10_GUITC	L1IDF8	L1JB10	Uncharacterized protein.	Thioredoxin domain-containing protein.	0.450
L1IDF8_GUITC	L1JCJ9_GUITC	L1IDF8	L1JCJ9	Uncharacterized protein.	Heat shock protein 70; Belongs to the heat shock protein 70 family.	0.545
L1IDF8_GUITC	L1JD81_GUITC	L1IDF8	L1JD81	Uncharacterized protein.	Heat shock protein 70; Belongs to the heat shock protein 70 family.	0.545
L1IDF8_GUITC	L1JSH8_GUITC	L1IDF8	L1JSH8	Uncharacterized protein.	Heat shock protein 70; Belongs to the heat shock protein 70 family.	0.545
L1IDF8_GUITC	L1JVY9_GUITC	L1IDF8	L1JVY9	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.421
L1IDF8_GUITC	TrxM	L1IDF8	L1J034	Uncharacterized protein.	Thioredoxin m.	0.672
L1IGW3_GUITC	L1IDF8_GUITC	L1IGW3	L1IDF8	Heat shock protein 70; Belongs to the heat shock protein 70 family.	Uncharacterized protein.	0.545
L1IGW3_GUITC	L1IM58_GUITC	L1IGW3	L1IM58	Heat shock protein 70; Belongs to the heat shock protein 70 family.	Thioredoxin-like_fold domain-containing protein.	0.545
L1IGW3_GUITC	L1IWP8_GUITC	L1IGW3	L1IWP8	Heat shock protein 70; Belongs to the heat shock protein 70 family.	Uncharacterized protein.	0.545
L1IGW3_GUITC	L1JB10_GUITC	L1IGW3	L1JB10	Heat shock protein 70; Belongs to the heat shock protein 70 family.	Thioredoxin domain-containing protein.	0.545
L1IGW3_GUITC	L1JVY9_GUITC	L1IGW3	L1JVY9	Heat shock protein 70; Belongs to the heat shock protein 70 family.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.633
L1IM58_GUITC	L1IGW3_GUITC	L1IM58	L1IGW3	Thioredoxin-like_fold domain-containing protein.	Heat shock protein 70; Belongs to the heat shock protein 70 family.	0.545
L1IM58_GUITC	L1JB10_GUITC	L1IM58	L1JB10	Thioredoxin-like_fold domain-containing protein.	Thioredoxin domain-containing protein.	0.517
L1IM58_GUITC	L1JCJ9_GUITC	L1IM58	L1JCJ9	Thioredoxin-like_fold domain-containing protein.	Heat shock protein 70; Belongs to the heat shock protein 70 family.	0.545
L1IM58_GUITC	L1JD81_GUITC	L1IM58	L1JD81	Thioredoxin-like_fold domain-containing protein.	Heat shock protein 70; Belongs to the heat shock protein 70 family.	0.545
L1IM58_GUITC	L1JSH8_GUITC	L1IM58	L1JSH8	Thioredoxin-like_fold domain-containing protein.	Heat shock protein 70; Belongs to the heat shock protein 70 family.	0.545
L1IM58_GUITC	L1JVY9_GUITC	L1IM58	L1JVY9	Thioredoxin-like_fold domain-containing protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.421
L1IM58_GUITC	TrxM	L1IM58	L1J034	Thioredoxin-like_fold domain-containing protein.	Thioredoxin m.	0.672
L1IWP8_GUITC	L1IGW3_GUITC	L1IWP8	L1IGW3	Uncharacterized protein.	Heat shock protein 70; Belongs to the heat shock protein 70 family.	0.545

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.828

expected number of edges:

12

PPI enrichment p-value:

0.00232

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032088

Negative regulation of NF-kappaB transcription factor activity

3 of 47

2.12

1.01

0.0130

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8873

COMM domain, and The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.

10 of 19

3.04

12.98

1.02e-25

CL:8878

COMM domain

8 of 10

3.22

10.99

3.24e-21

CL:8685

Neddylation, and Ankyrin repeat domain-containing protein AN34A/B/C

11 of 146

2.19

8.13

1.12e-21

CL:8882

COMM domain

3 of 5

3.1

3.05

2.89e-06

CL:8901

Mixed, incl. BRCA1-BARD1 complex, and Dendritic cell migration

2 of 5

2.92

1.45

0.0024

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8951664

Neddylation

11 of 406

1.75

4.62

1.08e-16

MAP-597592

Post-translational protein modification

11 of 2250

1.01

1.25

7.18e-09

MAP-392499

Metabolism of proteins

11 of 2844

0.91

1.02

6.26e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07258

COMM domain

8 of 10

3.22

10.77

8.85e-21

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017920

COMM domain

8 of 10

3.22

10.51

2.76e-20

IPR047155

COMM domain-containing protein 4/6/7/8

4 of 4

3.32

4.49

7.19e-09

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