L1JPE6_GUITC protein (Guillardia theta) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

L1JPE6_GUITC

Uncharacterized protein. (111 aa)

Predicted Functional Partners:

UBQ_RPS30e

0.999

RPL26e

0.990

RPL23Ae

0.990

RPL30e

0.990

RPL27e

0.990

RPL19e

0.990

RPL14e

0.990

RPL31e

0.990

RPL5e

0.989

RPL35A

0.989

Your Current Organism:

Guillardia theta

NCBI taxonomy Id: 905079
Other names: G. theta CCMP2712, Guillardia theta CCMP2712

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
L1JPE6_GUITC	RPL14e	L1JPE6	L1JWX7	Uncharacterized protein.	Large subunit ribosomal protein L14e, cytoplasmic.	0.990
L1JPE6_GUITC	RPL19e	L1JPE6	L1JVQ8	Uncharacterized protein.	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	0.990
L1JPE6_GUITC	RPL23Ae	L1JPE6	L1IGD0	Uncharacterized protein.	Large subunit ribosomal protein L23Ae, cytoplasmic; Belongs to the universal ribosomal protein uL23 family.	0.990
L1JPE6_GUITC	RPL26e	L1JPE6	L1I4Y1	Uncharacterized protein.	Large subunit ribosomal protein L26e, cytoplasmic.	0.990
L1JPE6_GUITC	RPL27e	L1JPE6	L1JNU8	Uncharacterized protein.	60S ribosomal protein L27; Belongs to the eukaryotic ribosomal protein eL27 family.	0.990
L1JPE6_GUITC	RPL30e	L1JPE6	L1JC58	Uncharacterized protein.	Large subunit ribosomal protein L30e, cytoplasmic.	0.990
L1JPE6_GUITC	RPL31e	L1JPE6	L1K1X1	Uncharacterized protein.	Large subunit ribosomal protein L31e, cytoplasmic.	0.990
L1JPE6_GUITC	RPL35A	L1JPE6	L1I611	Uncharacterized protein.	Large subunit ribosomal protein L35Ae, cytoplasmic.	0.989
L1JPE6_GUITC	RPL5e	L1JPE6	L1I3R0	Uncharacterized protein.	Large subunit ribosomal protein L5e, cytoplasmic.	0.989
L1JPE6_GUITC	UBQ_RPS30e	L1JPE6	L1JWJ6	Uncharacterized protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.999
RPL14e	L1JPE6_GUITC	L1JWX7	L1JPE6	Large subunit ribosomal protein L14e, cytoplasmic.	Uncharacterized protein.	0.990
RPL14e	RPL19e	L1JWX7	L1JVQ8	Large subunit ribosomal protein L14e, cytoplasmic.	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	0.999
RPL14e	RPL23Ae	L1JWX7	L1IGD0	Large subunit ribosomal protein L14e, cytoplasmic.	Large subunit ribosomal protein L23Ae, cytoplasmic; Belongs to the universal ribosomal protein uL23 family.	0.999
RPL14e	RPL26e	L1JWX7	L1I4Y1	Large subunit ribosomal protein L14e, cytoplasmic.	Large subunit ribosomal protein L26e, cytoplasmic.	0.999
RPL14e	RPL27e	L1JWX7	L1JNU8	Large subunit ribosomal protein L14e, cytoplasmic.	60S ribosomal protein L27; Belongs to the eukaryotic ribosomal protein eL27 family.	0.999
RPL14e	RPL30e	L1JWX7	L1JC58	Large subunit ribosomal protein L14e, cytoplasmic.	Large subunit ribosomal protein L30e, cytoplasmic.	0.999
RPL14e	RPL31e	L1JWX7	L1K1X1	Large subunit ribosomal protein L14e, cytoplasmic.	Large subunit ribosomal protein L31e, cytoplasmic.	0.999
RPL14e	RPL35A	L1JWX7	L1I611	Large subunit ribosomal protein L14e, cytoplasmic.	Large subunit ribosomal protein L35Ae, cytoplasmic.	0.999
RPL14e	RPL5e	L1JWX7	L1I3R0	Large subunit ribosomal protein L14e, cytoplasmic.	Large subunit ribosomal protein L5e, cytoplasmic.	0.999
RPL14e	UBQ_RPS30e	L1JWX7	L1JWJ6	Large subunit ribosomal protein L14e, cytoplasmic.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.852

expected number of edges:

24

PPI enrichment p-value:

0.0189

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006260

DNA replication

4 of 38

1.26

0.89

0.0056

GO:0090304

Nucleic acid metabolic process

10 of 248

0.84

0.82

1.68e-05

GO:0006259

DNA metabolic process

6 of 128

0.9

0.67

0.0044

GO:0009059

Macromolecule biosynthetic process

6 of 166

0.79

0.53

0.0123

GO:0044260

Cellular macromolecule metabolic process

8 of 295

0.67

0.49

0.0044

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140640

Catalytic activity, acting on a nucleic acid

9 of 154

1.0

1.08

4.70e-06

GO:0016779

Nucleotidyltransferase activity

4 of 31

1.34

1.06

0.0023

GO:0003677

DNA binding

9 of 185

0.92

0.94

1.13e-05

GO:0003697

Single-stranded DNA binding

2 of 4

1.93

0.85

0.0238

GO:0140097

Catalytic activity, acting on DNA

5 of 73

1.07

0.83

0.0027

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061695

Transferase complex, transferring phosphorus-containing groups

3 of 10

1.71

1.19

0.0034

GO:0000428

DNA-directed RNA polymerase complex

2 of 5

1.84

0.96

0.0133

GO:0140535

Intracellular protein-containing complex

3 of 20

1.41

0.95

0.0068

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:556

Mixed, incl. DNA replication, and Nucleotide excision repair

5 of 29

1.47

1.44

0.00024

CL:551

Mixed, incl. Catalytic activity, acting on DNA, and DNA replication

6 of 68

1.18

1.13

0.00024

CL:323

tRNA aminoacylation

3 of 15

1.53

0.95

0.0094

CL:558

Mixed, incl. Nucleotide excision repair, and Mre11 nuclease, N-terminal metallophosphatase domain

3 of 18

1.46

0.87

0.0126

CL:215

RNA polymerase

2 of 5

1.84

0.77

0.0328

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03030

DNA replication

4 of 22

1.49

1.3

0.00083

map03440

Homologous recombination

4 of 31

1.34

1.12

0.0014

map03020

RNA polymerase

2 of 4

1.93

0.96

0.0146

map03430

Mismatch repair

3 of 27

1.28

0.78

0.0146

map03410

Base excision repair

2 of 10

1.53

0.7

0.0377

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0548

Nucleotidyltransferase

4 of 21

1.51

1.27

0.0011

KW-0235

DNA replication

3 of 14

1.56

1.02

0.0065

KW-0240

DNA-directed RNA polymerase

2 of 5

1.84

0.92

0.0163

KW-0239

DNA-directed DNA polymerase

2 of 5

1.84

0.92

0.0163

KW-0234

DNA repair

3 of 23

1.35

0.82

0.0136

(more ...)

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