L1JPV4_GUITC protein (Guillardia theta) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Experiments

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Score

L1JPV4_GUITC

Uncharacterized protein. (523 aa)

Predicted Functional Partners:

L1J037_GUITC

0.969

L1IBX5_GUITC

0.932

L1I9G1_GUITC

0.884

L1JF55_GUITC

0.855

L1J0F8_GUITC

0.773

L1IDJ1_GUITC

0.695

L1IJ96_GUITC

0.694

L1IPU2_GUITC

0.657

L1IA49_GUITC

0.640

L1JBG7_GUITC

0.639

Your Current Organism:

Guillardia theta

NCBI taxonomy Id: 905079
Other names: G. theta CCMP2712, Guillardia theta CCMP2712

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
L1I9G1_GUITC	L1IA49_GUITC	L1I9G1	L1IA49	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.845
L1I9G1_GUITC	L1IDJ1_GUITC	L1I9G1	L1IDJ1	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.969
L1I9G1_GUITC	L1IJ96_GUITC	L1I9G1	L1IJ96	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.803
L1I9G1_GUITC	L1J037_GUITC	L1I9G1	L1J037	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.926
L1I9G1_GUITC	L1J0F8_GUITC	L1I9G1	L1J0F8	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.884
L1I9G1_GUITC	L1JBG7_GUITC	L1I9G1	L1JBG7	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.964
L1I9G1_GUITC	L1JF55_GUITC	L1I9G1	L1JF55	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.853
L1I9G1_GUITC	L1JPV4_GUITC	L1I9G1	L1JPV4	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.884
L1IA49_GUITC	L1I9G1_GUITC	L1IA49	L1I9G1	Uncharacterized protein.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.845
L1IA49_GUITC	L1IBX5_GUITC	L1IA49	L1IBX5	Uncharacterized protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.790
L1IA49_GUITC	L1IJ96_GUITC	L1IA49	L1IJ96	Uncharacterized protein.	Uncharacterized protein.	0.825
L1IA49_GUITC	L1J037_GUITC	L1IA49	L1J037	Uncharacterized protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.868
L1IA49_GUITC	L1J0F8_GUITC	L1IA49	L1J0F8	Uncharacterized protein.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.700
L1IA49_GUITC	L1JF55_GUITC	L1IA49	L1JF55	Uncharacterized protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.900
L1IA49_GUITC	L1JPV4_GUITC	L1IA49	L1JPV4	Uncharacterized protein.	Uncharacterized protein.	0.640
L1IBX5_GUITC	L1IA49_GUITC	L1IBX5	L1IA49	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.790
L1IBX5_GUITC	L1IDJ1_GUITC	L1IBX5	L1IDJ1	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.784
L1IBX5_GUITC	L1IJ96_GUITC	L1IBX5	L1IJ96	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.839
L1IBX5_GUITC	L1J0F8_GUITC	L1IBX5	L1J0F8	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.885
L1IBX5_GUITC	L1JBG7_GUITC	L1IBX5	L1JBG7	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.707

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Network Stats

number of nodes:

11

number of edges:

14

average node degree:

2.55

avg. local clustering coefficient:

0.887

expected number of edges:

10

PPI enrichment p-value:

0.144

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044772

Mitotic cell cycle phase transition

6 of 120

1.96

3.11

1.08e-07

GO:1905786

Positive regulation of anaphase-promoting complex-dependent catabolic process

3 of 3

3.26

3.06

2.90e-06

GO:0031145

Anaphase-promoting complex-dependent catabolic process

3 of 19

2.46

2.18

8.35e-05

GO:0000079

Regulation of cyclin-dependent protein serine/threonine kinase activity

4 of 73

2.0

2.16

3.82e-05

GO:0031396

Regulation of protein ubiquitination

5 of 171

1.73

2.06

1.76e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990757

Ubiquitin ligase activator activity

3 of 4

3.14

2.7

1.26e-05

GO:0010997

Anaphase-promoting complex binding

3 of 9

2.79

2.56

1.98e-05

GO:0016538

Cyclin-dependent protein serine/threonine kinase regulator activity

4 of 51

2.16

2.4

1.70e-05

GO:0043125

ErbB-3 class receptor binding

2 of 4

2.96

1.63

0.0011

GO:0030549

Acetylcholine receptor activator activity

2 of 4

2.96

1.63

0.0011

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000307

Cyclin-dependent protein kinase holoenzyme complex

6 of 51

2.33

4.66

2.70e-10

GO:0005680

Anaphase-promoting complex

3 of 21

2.42

2.26

5.31e-05

GO:1990234

Transferase complex

9 of 815

1.31

1.96

7.84e-09

GO:0016533

Protein kinase 5 complex

2 of 4

2.96

1.77

0.00062

GO:0031461

cullin-RING ubiquitin ligase complex

4 of 177

1.62

1.51

0.00037

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8864

Cell cycle, and Regulation of APC/C activators between G1/S and early anaphase

4 of 77

1.98

1.72

0.00035

CL:8865

Cell cycle, and Regulation of APC/C activators between G1/S and early anaphase

3 of 69

1.9

0.94

0.0158

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-176417

Phosphorylation of Emi1

2 of 7

2.72

1.12

0.0094

CFA-174113

SCF-beta-TrCP mediated degradation of Emi1

2 of 8

2.66

1.12

0.0094

CFA-69656

Cyclin A:Cdk2-associated events at S phase entry

3 of 65

1.93

1.05

0.0094

CFA-176407

Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase

2 of 20

2.26

0.9

0.0220

CFA-69231

Cyclin D associated events in G1

2 of 38

1.99

0.76

0.0370

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0195

Cyclin

3 of 34

2.21

1.79

0.00038

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00385

Domain present in cyclins, TFIIB and Retinoblastoma

3 of 42

2.12

1.49

0.0014

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