L1JRT5_GUITC protein (Guillardia theta) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

L1JRT5_GUITC

Uncharacterized protein. (276 aa)

Predicted Functional Partners:

L1IE81_GUITC

0.659

L1IXB3_GUITC

0.659

L1JLZ8_GUITC

0.522

L1J877_GUITC

0.446

L1IMP7_GUITC

0.401

Your Current Organism:

Guillardia theta

NCBI taxonomy Id: 905079
Other names: G. theta CCMP2712, Guillardia theta CCMP2712

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
L1IE81_GUITC	L1IXB3_GUITC	L1IE81	L1IXB3	Uncharacterized protein.	Uncharacterized protein.	0.905
L1IE81_GUITC	L1JRT5_GUITC	L1IE81	L1JRT5	Uncharacterized protein.	Uncharacterized protein.	0.659
L1IMP7_GUITC	L1JRT5_GUITC	L1IMP7	L1JRT5	PKS_ER domain-containing protein.	Uncharacterized protein.	0.401
L1IXB3_GUITC	L1IE81_GUITC	L1IXB3	L1IE81	Uncharacterized protein.	Uncharacterized protein.	0.905
L1IXB3_GUITC	L1JRT5_GUITC	L1IXB3	L1JRT5	Uncharacterized protein.	Uncharacterized protein.	0.659
L1J877_GUITC	L1JLZ8_GUITC	L1J877	L1JLZ8	ML domain-containing protein.	PKS_ER domain-containing protein.	0.534
L1J877_GUITC	L1JRT5_GUITC	L1J877	L1JRT5	ML domain-containing protein.	Uncharacterized protein.	0.446
L1JLZ8_GUITC	L1J877_GUITC	L1JLZ8	L1J877	PKS_ER domain-containing protein.	ML domain-containing protein.	0.534
L1JLZ8_GUITC	L1JRT5_GUITC	L1JLZ8	L1JRT5	PKS_ER domain-containing protein.	Uncharacterized protein.	0.522
L1JRT5_GUITC	L1IE81_GUITC	L1JRT5	L1IE81	Uncharacterized protein.	Uncharacterized protein.	0.659
L1JRT5_GUITC	L1IMP7_GUITC	L1JRT5	L1IMP7	Uncharacterized protein.	PKS_ER domain-containing protein.	0.401
L1JRT5_GUITC	L1IXB3_GUITC	L1JRT5	L1IXB3	Uncharacterized protein.	Uncharacterized protein.	0.659
L1JRT5_GUITC	L1J877_GUITC	L1JRT5	L1J877	Uncharacterized protein.	ML domain-containing protein.	0.446
L1JRT5_GUITC	L1JLZ8_GUITC	L1JRT5	L1JLZ8	Uncharacterized protein.	PKS_ER domain-containing protein.	0.522

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.856

expected number of edges:

11

PPI enrichment p-value:

1.8e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000413

Protein peptidyl-prolyl isomerization

5 of 29

2.46

3.83

5.95e-08

GO:0006607

NLS-bearing protein import into nucleus

4 of 16

2.62

3.3

9.58e-07

GO:0051642

Centrosome localization

4 of 34

2.29

2.8

4.84e-06

GO:0006111

Regulation of gluconeogenesis

4 of 36

2.27

2.78

4.84e-06

GO:0051028

mRNA transport

5 of 83

2.0

2.74

2.06e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061665

SUMO ligase activity

4 of 13

2.71

3.52

4.17e-07

GO:0031267

Small GTPase binding

4 of 230

1.46

0.99

0.0067

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044614

Nuclear pore cytoplasmic filaments

5 of 6

3.14

6.07

1.46e-11

GO:0005642

Annulate lamellae

4 of 7

2.98

4.39

1.44e-08

GO:0106068

SUMO ligase complex

4 of 11

2.78

4.09

3.97e-08

GO:0042405

Nuclear inclusion body

4 of 11

2.78

4.09

3.97e-08

GO:0044615

Nuclear pore nuclear basket

4 of 13

2.71

4.06

3.97e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5955

Transport of Mature mRNA Derived from an Intronless Transcript

5 of 35

2.38

3.77

5.74e-08

CL:5958

Transport of Mature mRNA Derived from an Intronless Transcript

4 of 29

2.36

3.17

1.01e-06

CL:5999

Mixed, incl. Nuclear pore central transport channel, and Nuclear pore cytoplasmic filaments

2 of 7

2.68

1.43

0.0029

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-159236

Transport of Mature mRNA derived from an Intron-Containing Transcript

5 of 60

2.14

3.22

3.24e-07

MAP-72202

Transport of Mature Transcript to Cytoplasm

5 of 65

2.11

3.18

3.24e-07

MAP-159231

Transport of Mature mRNA Derived from an Intronless Transcript

4 of 40

2.22

2.75

4.93e-06

MAP-3301854

Nuclear Pore Complex (NPC) Disassembly

4 of 41

2.21

2.74

4.93e-06

MAP-159227

Transport of the SLBP independent Mature mRNA

4 of 41

2.21

2.74

4.93e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0044614

Nuclear pore cytoplasmic filaments

4 of 5

3.12

4.45

1.28e-08

GOCC:0005643

Nuclear pore

5 of 54

2.19

3.5

9.09e-08

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045255

Ran binding protein RanBP1-like

3 of 8

2.79

2.14

0.00016

IPR000156

Ran binding domain

3 of 8

2.79

2.14

0.00016

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00160

Ran-binding domain

3 of 8

2.79

2.65

1.88e-05

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