L1JVC5_GUITC protein (Guillardia theta) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Score

L1JVC5_GUITC

Uncharacterized protein. (247 aa)

Predicted Functional Partners:

L1K252_GUITC

0.508

L1JES3_GUITC

0.506

L1IL15_GUITC

0.450

L1JK44_GUITC

0.450

L1JVY9_GUITC

0.422

L1IZP4_GUITC

0.421

Your Current Organism:

Guillardia theta

NCBI taxonomy Id: 905079
Other names: G. theta CCMP2712, Guillardia theta CCMP2712

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
L1IL15_GUITC	L1JES3_GUITC	L1IL15	L1JES3	Nudix hydrolase domain-containing protein.	Uncharacterized protein.	0.985
L1IL15_GUITC	L1JK44_GUITC	L1IL15	L1JK44	Nudix hydrolase domain-containing protein.	Nudix hydrolase domain-containing protein.	0.908
L1IL15_GUITC	L1JVC5_GUITC	L1IL15	L1JVC5	Nudix hydrolase domain-containing protein.	Uncharacterized protein.	0.450
L1IL15_GUITC	L1K252_GUITC	L1IL15	L1K252	Nudix hydrolase domain-containing protein.	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family.	0.987
L1IZP4_GUITC	L1JVC5_GUITC	L1IZP4	L1JVC5	Uncharacterized protein.	Uncharacterized protein.	0.421
L1JES3_GUITC	L1IL15_GUITC	L1JES3	L1IL15	Uncharacterized protein.	Nudix hydrolase domain-containing protein.	0.985
L1JES3_GUITC	L1JK44_GUITC	L1JES3	L1JK44	Uncharacterized protein.	Nudix hydrolase domain-containing protein.	0.985
L1JES3_GUITC	L1JVC5_GUITC	L1JES3	L1JVC5	Uncharacterized protein.	Uncharacterized protein.	0.506
L1JES3_GUITC	L1K252_GUITC	L1JES3	L1K252	Uncharacterized protein.	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family.	0.999
L1JK44_GUITC	L1IL15_GUITC	L1JK44	L1IL15	Nudix hydrolase domain-containing protein.	Nudix hydrolase domain-containing protein.	0.908
L1JK44_GUITC	L1JES3_GUITC	L1JK44	L1JES3	Nudix hydrolase domain-containing protein.	Uncharacterized protein.	0.985
L1JK44_GUITC	L1JVC5_GUITC	L1JK44	L1JVC5	Nudix hydrolase domain-containing protein.	Uncharacterized protein.	0.450
L1JK44_GUITC	L1K252_GUITC	L1JK44	L1K252	Nudix hydrolase domain-containing protein.	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family.	0.987
L1JVC5_GUITC	L1IL15_GUITC	L1JVC5	L1IL15	Uncharacterized protein.	Nudix hydrolase domain-containing protein.	0.450
L1JVC5_GUITC	L1IZP4_GUITC	L1JVC5	L1IZP4	Uncharacterized protein.	Uncharacterized protein.	0.421
L1JVC5_GUITC	L1JES3_GUITC	L1JVC5	L1JES3	Uncharacterized protein.	Uncharacterized protein.	0.506
L1JVC5_GUITC	L1JK44_GUITC	L1JVC5	L1JK44	Uncharacterized protein.	Nudix hydrolase domain-containing protein.	0.450
L1JVC5_GUITC	L1JVY9_GUITC	L1JVC5	L1JVY9	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.422
L1JVC5_GUITC	L1K252_GUITC	L1JVC5	L1K252	Uncharacterized protein.	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family.	0.508
L1JVY9_GUITC	L1JVC5_GUITC	L1JVY9	L1JVC5	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Uncharacterized protein.	0.422

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Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.84

expected number of edges:

11

PPI enrichment p-value:

2.39e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044743

Protein transmembrane import into intracellular organelle

5 of 38

2.44

3.68

6.87e-08

GO:0065002

Intracellular protein transmembrane transport

5 of 53

2.29

3.4

1.63e-07

GO:0006626

Protein targeting to mitochondrion

4 of 46

2.26

2.5

1.34e-05

GO:0030150

Protein import into mitochondrial matrix

3 of 21

2.47

2.12

0.00011

GO:0006605

Protein targeting

5 of 172

1.78

2.1

1.90e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051087

Chaperone binding

5 of 71

2.17

3.11

4.32e-07

GO:0004176

ATP-dependent peptidase activity

3 of 9

2.84

2.68

1.22e-05

GO:0140662

ATP-dependent protein folding chaperone

3 of 33

2.28

2.02

0.00014

GO:0140657

ATP-dependent activity

7 of 608

1.38

1.73

3.96e-06

GO:0051082

Unfolded protein binding

3 of 98

1.8

1.32

0.0020

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005759

Mitochondrial matrix

8 of 304

1.74

3.41

2.20e-10

GO:0005739

Mitochondrion

10 of 1452

1.16

1.59

7.23e-09

GO:0005743

Mitochondrial inner membrane

5 of 419

1.39

1.41

0.00016

GO:0005740

Mitochondrial envelope

6 of 673

1.27

1.35

5.72e-05

GO:0042645

Mitochondrial nucleoid

2 of 33

2.1

1.0

0.0130

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1894

Clp ATPase, C-terminal, and Endopeptidase Clp complex

4 of 5

3.22

4.26

1.82e-08

CL:6549

TIM23 mitochondrial import inner membrane translocase complex, and Tim44-like

4 of 10

2.92

3.98

4.62e-08

CL:1823

Mixed, incl. Chaperone cofactor-dependent protein refolding, and DnaJ domain, conserved site

5 of 43

2.38

3.76

3.76e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9609507

Protein localization

6 of 201

1.79

2.68

3.79e-07

MAP-1268020

Mitochondrial protein import

4 of 47

2.25

2.66

5.95e-06

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000862

Heart ventricle

2 of 192

1.34

0.67

0.0337

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005759

Mitochondrial matrix

7 of 205

1.85

3.43

2.61e-09

GOCC:0005739

Mitochondrion

8 of 936

1.25

1.63

4.35e-07

GOCC:0070013

Intracellular organelle lumen

9 of 1388

1.13

1.39

4.35e-07

GOCC:0005740

Mitochondrial envelope

4 of 383

1.34

0.92

0.0062

GOCC:0005743

Mitochondrial inner membrane

3 of 213

1.47

0.78

0.0221

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0496

Mitochondrion

4 of 160

1.72

1.63

0.00027

KW-0720

Serine protease

3 of 78

1.9

1.46

0.0012

KW-0811

Translocation

2 of 20

2.32

1.22

0.0054

KW-0143

Chaperone

2 of 22

2.28

1.22

0.0054

KW-0999

Mitochondrion inner membrane

2 of 56

1.87

0.89

0.0192

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039544

Tim44-like

2 of 2

3.32

1.14

0.0090

IPR027065

Lon protease

2 of 2

3.32

1.14

0.0090

IPR017303

Mitochondrial import inner membrane translocase subunit Tim44

2 of 2

3.32

1.14

0.0090

IPR008269

Peptidase S16, Lon proteolytic domain

2 of 2

3.32

1.14

0.0090

IPR008268

Peptidase S16, active site

2 of 2

3.32

1.14

0.0090

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00978

Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane PUBMED:10430866. Tim44 is thought to bind phospholipids of the mitochondrial inner membrane both by ...

2 of 3

3.14

1.55

0.0016

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