L1JZE3_GUITC protein (Guillardia theta) - STRING interaction network

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

L1JZE3_GUITC

Aminotran_1_2 domain-containing protein. (497 aa)

Predicted Functional Partners:

L1IGW8_GUITC

0.975

L1INW1_GUITC

0.975

L1JZR7_GUITC

0.975

L1K4F8_GUITC

0.975

L1K425_GUITC

0.921

L1JCX8_GUITC

0.903

L1JS25_GUITC

0.903

L1IPV7_GUITC

0.901

L1K2F3_GUITC

0.846

L1IAQ7_GUITC

0.843

Your Current Organism:

Guillardia theta

NCBI taxonomy Id: 905079
Other names: G. theta CCMP2712, Guillardia theta CCMP2712

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
L1IAQ7_GUITC	L1IGW8_GUITC	L1IAQ7	L1IGW8	Lyase_1 domain-containing protein.	Aspartate aminotransferase.	0.901
L1IAQ7_GUITC	L1INW1_GUITC	L1IAQ7	L1INW1	Lyase_1 domain-containing protein.	Aspartate aminotransferase.	0.901
L1IAQ7_GUITC	L1IPV7_GUITC	L1IAQ7	L1IPV7	Lyase_1 domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.843
L1IAQ7_GUITC	L1JCX8_GUITC	L1IAQ7	L1JCX8	Lyase_1 domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.843
L1IAQ7_GUITC	L1JS25_GUITC	L1IAQ7	L1JS25	Lyase_1 domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.843
L1IAQ7_GUITC	L1JZE3_GUITC	L1IAQ7	L1JZE3	Lyase_1 domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.843
L1IAQ7_GUITC	L1JZR7_GUITC	L1IAQ7	L1JZR7	Lyase_1 domain-containing protein.	Aspartate aminotransferase.	0.901
L1IAQ7_GUITC	L1K2F3_GUITC	L1IAQ7	L1K2F3	Lyase_1 domain-containing protein.	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.998
L1IAQ7_GUITC	L1K425_GUITC	L1IAQ7	L1K425	Lyase_1 domain-containing protein.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.450
L1IAQ7_GUITC	L1K4F8_GUITC	L1IAQ7	L1K4F8	Lyase_1 domain-containing protein.	Aspartate aminotransferase.	0.901
L1IGW8_GUITC	L1IAQ7_GUITC	L1IGW8	L1IAQ7	Aspartate aminotransferase.	Lyase_1 domain-containing protein.	0.901
L1IGW8_GUITC	L1INW1_GUITC	L1IGW8	L1INW1	Aspartate aminotransferase.	Aspartate aminotransferase.	0.904
L1IGW8_GUITC	L1IPV7_GUITC	L1IGW8	L1IPV7	Aspartate aminotransferase.	Aminotran_1_2 domain-containing protein.	0.975
L1IGW8_GUITC	L1JCX8_GUITC	L1IGW8	L1JCX8	Aspartate aminotransferase.	Aminotran_1_2 domain-containing protein.	0.975
L1IGW8_GUITC	L1JS25_GUITC	L1IGW8	L1JS25	Aspartate aminotransferase.	Aminotran_1_2 domain-containing protein.	0.975
L1IGW8_GUITC	L1JZE3_GUITC	L1IGW8	L1JZE3	Aspartate aminotransferase.	Aminotran_1_2 domain-containing protein.	0.975
L1IGW8_GUITC	L1JZR7_GUITC	L1IGW8	L1JZR7	Aspartate aminotransferase.	Aspartate aminotransferase.	0.904
L1IGW8_GUITC	L1K2F3_GUITC	L1IGW8	L1K2F3	Aspartate aminotransferase.	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.890
L1IGW8_GUITC	L1K425_GUITC	L1IGW8	L1K425	Aspartate aminotransferase.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.943
L1IGW8_GUITC	L1K4F8_GUITC	L1IGW8	L1K4F8	Aspartate aminotransferase.	Aspartate aminotransferase.	0.903

page 1 of 6

Network Stats

number of nodes:

5

number of edges:

7

average node degree:

2.8

avg. local clustering coefficient:

0.767

expected number of edges:

4

PPI enrichment p-value:

0.124

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070330

Aromatase activity

3 of 11

2.61

1.99

0.00021

GO:0020037

Heme binding

4 of 113

1.73

1.42

0.00099

GO:0005506

Iron ion binding

3 of 127

1.55

0.73

0.0319

GO:0003824

Catalytic activity

10 of 5203

0.46

0.31

0.0319

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30660177

(2019) Isolation of blue-green eggshell pigmentation-related genes from Putian duck through RNA-seq.

4 of 25

2.38

2.49

1.79e-05

PMID:33782952

(2021) Antimicrobial prescribing guidelines for poultry.

2 of 2

3.18

1.14

0.0088

PMID:34214746

(2021) Protective effect of glutathione S-transferase enzyme activity against aflatoxin B1 in poultry species: relationship between glutathione S-transferase enzyme kinetic parameters, and resistance to aflatoxin B1.

2 of 5

2.78

0.93

0.0204

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9381

Mixed, incl. Sulfation, and Epoxygenase P450 pathway

4 of 23

2.42

2.71

6.67e-06

CL:9383

Sulfation, and Epoxygenase P450 pathway

3 of 8

2.75

2.28

6.55e-05

CL:8025

Cytochrome P450, E-class, CYP3A, and Cytochrome P450, E-class, group I, CYP1

2 of 5

2.78

1.1

0.0103

CL:8590

Protoporphyrinogen IX biosynthetic process, and Heme transport

2 of 12

2.4

0.81

0.0333

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla00591

Linoleic acid metabolism

2 of 13

2.37

1.17

0.0069

apla00980

Metabolism of xenobiotics by cytochrome P450

2 of 22

2.14

1.09

0.0090

apla00830

Retinol metabolism

2 of 23

2.12

1.09

0.0090

apla00140

Steroid hormone biosynthesis

2 of 27

2.05

1.08

0.0090

apla01100

Metabolic pathways

5 of 996

0.88

0.61

0.0090

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-211859

Biological oxidations

8 of 192

1.8

3.67

1.02e-10

MAP-9749641

Aspirin ADME

4 of 21

2.46

3.12

1.09e-06

MAP-5423646

Aflatoxin activation and detoxification

3 of 14

2.51

2.19

8.12e-05

MAP-9757110

Prednisone ADME

3 of 20

2.36

2.11

0.00010

MAP-156580

Phase II - Conjugation of compounds

4 of 77

1.89

1.95

8.12e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0503

Monooxygenase

3 of 43

2.02

1.53

0.0010

KW-0349

Heme

3 of 60

1.88

1.43

0.0013

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00067

Cytochrome P450

3 of 45

2.0

1.12

0.0071

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008072

Cytochrome P450, E-class, CYP3A

2 of 2

3.18

1.07

0.0118

IPR002402

Cytochrome P450, E-class, group II

2 of 2

3.18

1.07

0.0118

IPR017972

Cytochrome P450, conserved site

3 of 36

2.1

1.02

0.0118

IPR036396

Cytochrome P450 superfamily

3 of 46

1.99

1.01

0.0118

IPR001128

Cytochrome P450

3 of 45

2.0

1.01

0.0118

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