Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SHHSonic hedgehog signaling molecule. (423 aa)    
Predicted Functional Partners:
PTCH1
Patched 1.
    
 0.998
DISP1
Dispatched RND transporter family member 1.
    
 0.990
PTCH2
Patched 2.
    
 0.989
CDON
Cell adhesion associated, oncogene regulated.
    
 0.987
BOC
BOC cell adhesion associated, oncogene regulated.
    
 0.983
SMO
Smoothened, frizzled class receptor.
    
 0.972
ENSPCLP00000005939
annotation not available
    
 0.953
GLI1
GLI family zinc finger 1.
   
 0.953
GAS1
Growth arrest specific 1.
    
 0.951
HHIP
Hedgehog interacting protein.
    
 0.926
Your Current Organism:
Phasianus colchicus
NCBI taxonomy Id: 9054
Other names: P. colchicus, Ring-necked pheasant, common pheasant
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.