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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. (4861 aa)    
Predicted Functional Partners:
RNF8
Ring finger protein 8.
   
 0.776
RANBP2
RAN binding protein 2.
   
 0.634
PIAS4
Protein inhibitor of activated STAT 4.
    
 0.610
UBE3A
Ubiquitin protein ligase E3A.
   
0.600
BRCA1
BRCA1 DNA repair associated.
    
 0.592
DOCK10
Dedicator of cytokinesis 10.
    
   0.586
ENSPCLP00000011369
annotation not available
    
  0.580
ENSPCLP00000015797
annotation not available
    
 0.574
USP38
Ubiquitin specific peptidase 38.
    
   0.549
BARD1
BRCA1 associated RING domain 1.
    
 0.543
Your Current Organism:
Phasianus colchicus
NCBI taxonomy Id: 9054
Other names: P. colchicus, Ring-necked pheasant, common pheasant
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.