MA16_Dca022549 protein (Dendrobium catenatum)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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Score

MA16_Dca022549

Importin N-terminal domain-containing protein. (1073 aa)

Predicted Functional Partners:

RAN3

0.983

MA16_Dca004343

0.939

MA16_Dca024480

0.922

MA16_Dca001516

0.922

MA16_Dca018932

0.900

RAN-B1

0.843

RAN-B1-2

0.843

MA16_Dca003017

0.786

RANGAP1-2

0.765

LYK3

0.715

Your Current Organism:

Dendrobium catenatum

NCBI taxonomy Id: 906689
Other names: D. catenatum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LYK3	MA16_Dca022549	A0A2I0VER1	A0A2I0VGB3	LysM domain receptor-like kinase 3.	Importin N-terminal domain-containing protein.	0.715
MA16_Dca001516	MA16_Dca003017	A0A2I0WMM0	A0A2I0X9D3	C2H2-type domain-containing protein.	Uncharacterized protein.	0.883
MA16_Dca001516	MA16_Dca004343	A0A2I0WMM0	A0A2I0W777	C2H2-type domain-containing protein.	Uncharacterized protein.	0.973
MA16_Dca001516	MA16_Dca022549	A0A2I0WMM0	A0A2I0VGB3	C2H2-type domain-containing protein.	Importin N-terminal domain-containing protein.	0.922
MA16_Dca001516	RAN-B1	A0A2I0WMM0	A0A2I0V9Q6	C2H2-type domain-containing protein.	GTP-binding nuclear protein Ran-B1.	0.746
MA16_Dca001516	RAN-B1-2	A0A2I0WMM0	A0A2I0W888	C2H2-type domain-containing protein.	GTP-binding nuclear protein Ran-B1.	0.746
MA16_Dca001516	RAN3	A0A2I0WMM0	A0A2I0WZ75	C2H2-type domain-containing protein.	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.746
MA16_Dca001516	RANGAP1-2	A0A2I0WMM0	A0A2I0W0A9	C2H2-type domain-containing protein.	RAN GTPase-activating protein 1.	0.706
MA16_Dca003017	MA16_Dca001516	A0A2I0X9D3	A0A2I0WMM0	Uncharacterized protein.	C2H2-type domain-containing protein.	0.883
MA16_Dca003017	MA16_Dca004343	A0A2I0X9D3	A0A2I0W777	Uncharacterized protein.	Uncharacterized protein.	0.631
MA16_Dca003017	MA16_Dca022549	A0A2I0X9D3	A0A2I0VGB3	Uncharacterized protein.	Importin N-terminal domain-containing protein.	0.786
MA16_Dca003017	MA16_Dca024480	A0A2I0X9D3	A0A2I0V9A6	Uncharacterized protein.	C2H2-type domain-containing protein.	0.883
MA16_Dca003017	RAN-B1	A0A2I0X9D3	A0A2I0V9Q6	Uncharacterized protein.	GTP-binding nuclear protein Ran-B1.	0.633
MA16_Dca003017	RAN-B1-2	A0A2I0X9D3	A0A2I0W888	Uncharacterized protein.	GTP-binding nuclear protein Ran-B1.	0.633
MA16_Dca003017	RAN3	A0A2I0X9D3	A0A2I0WZ75	Uncharacterized protein.	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.633
MA16_Dca003017	RANGAP1-2	A0A2I0X9D3	A0A2I0W0A9	Uncharacterized protein.	RAN GTPase-activating protein 1.	0.536
MA16_Dca004343	MA16_Dca001516	A0A2I0W777	A0A2I0WMM0	Uncharacterized protein.	C2H2-type domain-containing protein.	0.973
MA16_Dca004343	MA16_Dca003017	A0A2I0W777	A0A2I0X9D3	Uncharacterized protein.	Uncharacterized protein.	0.631
MA16_Dca004343	MA16_Dca018932	A0A2I0W777	A0A2I0VU62	Uncharacterized protein.	Uncharacterized protein.	0.929
MA16_Dca004343	MA16_Dca022549	A0A2I0W777	A0A2I0VGB3	Uncharacterized protein.	Importin N-terminal domain-containing protein.	0.939

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

17

PPI enrichment p-value:

5.71e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043161

Proteasome-mediated ubiquitin-dependent protein catabolic process

10 of 153

1.87

5.08

6.75e-16

GO:0043248

Proteasome assembly

5 of 17

2.53

4.59

1.13e-09

GO:0006511

Ubiquitin-dependent protein catabolic process

11 of 230

1.74

4.47

3.75e-16

GO:0045862

Positive regulation of proteolysis

5 of 25

2.36

4.13

5.36e-09

GO:0070682

Proteasome regulatory particle assembly

4 of 9

2.71

3.92

4.34e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0036402

Proteasome-activating activity

4 of 6

2.88

3.78

1.07e-07

GO:0016887

ATP hydrolysis activity

4 of 190

1.38

0.83

0.0134

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000502

Proteasome complex

11 of 37

2.53

10.95

6.26e-25

GO:0005838

Proteasome regulatory particle

9 of 21

2.69

9.89

7.78e-21

GO:0008540

Proteasome regulatory particle, base subcomplex

5 of 9

2.8

5.52

3.76e-11

GO:0008541

Proteasome regulatory particle, lid subcomplex

4 of 11

2.62

3.9

4.09e-08

GO:0034515

Proteasome storage granule

4 of 14

2.51

3.71

7.63e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2026

Proteasome complex

11 of 34

2.57

11.12

6.42e-25

CL:2028

Proteasome complex

10 of 26

2.64

10.74

3.36e-23

CL:2030

Proteasome accessory complex

8 of 14

2.81

9.25

8.31e-19

CL:2032

Proteasome regulatory particle, base subcomplex, and Proteasome regulatory particle, lid subcomplex

6 of 8

2.93

7.07

4.93e-14

CL:2058

Proteasome subunit

2 of 11

2.32

1.09

0.0096

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03050

Proteasome

11 of 42

2.48

10.75

3.86e-25

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1236978

Cross-presentation of soluble exogenous antigens (endosomes)

11 of 41

2.49

10.56

1.85e-24

MAP-1236975

Antigen processing-Cross presentation

11 of 42

2.48

10.51

1.85e-24

MAP-5689880

Ub-specific processing proteases

11 of 81

2.19

8.19

5.49e-22

MAP-5688426

Deubiquitination

11 of 117

2.03

6.87

1.86e-20

MAP-983169

Class I MHC mediated antigen processing & presentation

11 of 191

1.82

5.23

2.66e-18

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000502

Proteasome complex

11 of 108

2.07

7.01

3.47e-20

GOCC:0005838

Proteasome regulatory particle

6 of 14

2.69

6.24

8.27e-13

GOCC:0008540

Proteasome regulatory particle, base subcomplex

5 of 10

2.76

5.34

7.67e-11

GOCC:0005839

Proteasome core complex

2 of 15

2.18

1.06

0.0106

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0888

Threonine protease

2 of 12

2.28

0.98

0.0153

KW-0647

Proteasome

2 of 13

2.24

0.98

0.0153

KW-0067

ATP-binding

4 of 304

1.18

0.73

0.0153

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005937

26S proteasome regulatory subunit P45-like

4 of 6

2.88

3.64

1.92e-07

IPR003960

ATPase, AAA-type, conserved site

4 of 20

2.36

2.76

4.82e-06

IPR032501

Proteasomal ATPase OB C-terminal domain

3 of 5

2.84

2.5

2.68e-05

IPR003959

ATPase, AAA-type, core

4 of 49

1.97

2.04

6.56e-05

IPR041569

AAA ATPase, AAA+ lid domain

3 of 15

2.36

1.97

0.00019

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

4 of 120

1.58

1.34

0.00094

SM00088

Motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

2 of 13

2.24

1.03

0.0121

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