BIG3 protein (Dendrobium catenatum) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

BIG3

Brefeldin A-inhibited guanine nucleotide-exchange protein 3. (1860 aa)

Predicted Functional Partners:

MA16_Dca018623

0.478

LPAT1

0.478

GNL2

0.475

ATJ39-3

0.462

ARF1-3

0.420

ARF-5

0.420

ARF1

0.416

ARF

0.416

MA16_Dca006890

0.416

ARF-2

0.416

Your Current Organism:

Dendrobium catenatum

NCBI taxonomy Id: 906689
Other names: D. catenatum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARF	BIG3	A0A2I0VST3	A0A2I0WBW0	ADP-ribosylation factor 2; Belongs to the small GTPase superfamily. Arf family.	Brefeldin A-inhibited guanine nucleotide-exchange protein 3.	0.416
ARF	GNL2	A0A2I0VST3	A0A2I0WH63	ADP-ribosylation factor 2; Belongs to the small GTPase superfamily. Arf family.	ARF guanine-nucleotide exchange factor GNL2.	0.601
ARF-2	BIG3	A0A2I0VU55	A0A2I0WBW0	ADP-ribosylation factor; Belongs to the small GTPase superfamily. Arf family.	Brefeldin A-inhibited guanine nucleotide-exchange protein 3.	0.416
ARF-2	GNL2	A0A2I0VU55	A0A2I0WH63	ADP-ribosylation factor; Belongs to the small GTPase superfamily. Arf family.	ARF guanine-nucleotide exchange factor GNL2.	0.601
ARF-5	BIG3	A0A2I0WNK7	A0A2I0WBW0	ADP-ribosylation factor 2; Belongs to the small GTPase superfamily. Arf family.	Brefeldin A-inhibited guanine nucleotide-exchange protein 3.	0.420
ARF-5	GNL2	A0A2I0WNK7	A0A2I0WH63	ADP-ribosylation factor 2; Belongs to the small GTPase superfamily. Arf family.	ARF guanine-nucleotide exchange factor GNL2.	0.645
ARF1	BIG3	A0A2I0VJ24	A0A2I0WBW0	ADP-ribosylation factor 1.	Brefeldin A-inhibited guanine nucleotide-exchange protein 3.	0.416
ARF1	GNL2	A0A2I0VJ24	A0A2I0WH63	ADP-ribosylation factor 1.	ARF guanine-nucleotide exchange factor GNL2.	0.601
ARF1-3	BIG3	A0A2I0W0U3	A0A2I0WBW0	ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family.	Brefeldin A-inhibited guanine nucleotide-exchange protein 3.	0.420
ARF1-3	GNL2	A0A2I0W0U3	A0A2I0WH63	ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family.	ARF guanine-nucleotide exchange factor GNL2.	0.645
ATJ39-3	BIG3	A0A2I0WDG6	A0A2I0WBW0	Chaperone protein dnaJ 39.	Brefeldin A-inhibited guanine nucleotide-exchange protein 3.	0.462
BIG3	ARF	A0A2I0WBW0	A0A2I0VST3	Brefeldin A-inhibited guanine nucleotide-exchange protein 3.	ADP-ribosylation factor 2; Belongs to the small GTPase superfamily. Arf family.	0.416
BIG3	ARF-2	A0A2I0WBW0	A0A2I0VU55	Brefeldin A-inhibited guanine nucleotide-exchange protein 3.	ADP-ribosylation factor; Belongs to the small GTPase superfamily. Arf family.	0.416
BIG3	ARF-5	A0A2I0WBW0	A0A2I0WNK7	Brefeldin A-inhibited guanine nucleotide-exchange protein 3.	ADP-ribosylation factor 2; Belongs to the small GTPase superfamily. Arf family.	0.420
BIG3	ARF1	A0A2I0WBW0	A0A2I0VJ24	Brefeldin A-inhibited guanine nucleotide-exchange protein 3.	ADP-ribosylation factor 1.	0.416
BIG3	ARF1-3	A0A2I0WBW0	A0A2I0W0U3	Brefeldin A-inhibited guanine nucleotide-exchange protein 3.	ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family.	0.420
BIG3	ATJ39-3	A0A2I0WBW0	A0A2I0WDG6	Brefeldin A-inhibited guanine nucleotide-exchange protein 3.	Chaperone protein dnaJ 39.	0.462
BIG3	GNL2	A0A2I0WBW0	A0A2I0WH63	Brefeldin A-inhibited guanine nucleotide-exchange protein 3.	ARF guanine-nucleotide exchange factor GNL2.	0.475
BIG3	LPAT1	A0A2I0WBW0	A0A2I0WPD4	Brefeldin A-inhibited guanine nucleotide-exchange protein 3.	1-acyl-sn-glycerol-3-phosphate acyltransferase 1, chloroplastic.	0.478
BIG3	MA16_Dca006890	A0A2I0WBW0	A0A2I0VT33	Brefeldin A-inhibited guanine nucleotide-exchange protein 3.	ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family.	0.416

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Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.706

expected number of edges:

15

PPI enrichment p-value:

0.000868

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006753

Nucleoside phosphate metabolic process

6 of 153

1.46

1.56

7.44e-05

GO:0009117

Nucleotide metabolic process

5 of 148

1.39

1.33

0.00031

GO:0019637

Organophosphate metabolic process

7 of 328

1.19

1.22

9.41e-05

GO:0009259

Ribonucleotide metabolic process

4 of 110

1.42

1.07

0.0031

GO:0000290

Deadenylation-dependent decapping of nuclear-transcribed mRNA

2 of 8

2.26

1.06

0.0106

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0052857

NADPHX epimerase activity

2 of 2

2.86

1.02

0.0146

GO:0052856

NADHX epimerase activity

2 of 2

2.86

1.02

0.0146

GO:0004551

Nucleotide diphosphatase activity

2 of 5

2.46

0.97

0.0170

GO:0047429

Nucleoside-triphosphate diphosphatase activity

2 of 6

2.39

0.96

0.0170

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9541

Mixed, incl. AMP metabolic process, and GMP biosynthesis

3 of 16

2.14

1.71

0.00049

CL:5292

mRNA decay by 5 to 3 exoribonuclease, and U6 snRNP

3 of 17

2.11

1.7

0.00049

CL:9538

Metabolism of nucleotides, and Purine nucleoside metabolic process

4 of 45

1.81

1.65

0.00033

CL:9534

Mixed, incl. Metabolism of nucleotides, and Nicotinate and nicotinamide metabolism

5 of 111

1.52

1.44

0.00033

CL:5315

Stress granule assembly, and Deadenylation-independent decapping of nuclear-transcribed mRNA

2 of 5

2.46

1.28

0.0044

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00240

Pyrimidine metabolism

3 of 58

1.58

0.95

0.0099

map03018

RNA degradation

3 of 85

1.41

0.83

0.0148

map00230

Purine metabolism

3 of 88

1.4

0.82

0.0148

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000932

P-body

3 of 17

2.11

1.41

0.0020

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0665

Pyrimidine biosynthesis

2 of 3

2.69

1.33

0.0038

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