STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RECQL4A-2ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (290 aa)    
Predicted Functional Partners:
RECQL4A
ATP-dependent DNA helicase Q-like 4A.
 
     0.950
UPF1
Regulator of nonsense transcripts 1 like.
   
 0.840
MA16_Dca002063
RMI1_N domain-containing protein.
    
 0.826
MA16_Dca009840
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
  
 0.823
EXO1
Exonuclease 1.
  
 0.822
EXO1-2
Exonuclease 1.
  
 0.822
MA16_Dca003242
DNA topoisomerase I.
  
 0.781
MUS81
Crossover junction endonuclease MUS81.
   
 0.778
RAD50
DNA repair protein RAD50.
  
 0.769
FEN-1a
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
  
 0.752
Your Current Organism:
Dendrobium catenatum
NCBI taxonomy Id: 906689
Other names: D. catenatum
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