BRE1B-2 protein (Dendrobium catenatum) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

BRE1B-2

E3 ubiquitin protein ligase. (178 aa)

Predicted Functional Partners:

UBC2

0.762

UBC2-2

0.762

UBC1

0.762

UBC2-3

0.762

MA16_Dca021212

0.761

MA16_Dca001968

0.737

MA16_Dca000853

0.712

MA16_Dca019121

0.696

MED35C-2

0.681

UBC27

0.615

Your Current Organism:

Dendrobium catenatum

NCBI taxonomy Id: 906689
Other names: D. catenatum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRE1B-2	MA16_Dca000853	A0A2I0XJK2	A0A2I0WV21	E3 ubiquitin protein ligase.	Uncharacterized protein.	0.712
BRE1B-2	MA16_Dca001968	A0A2I0XJK2	A0A2I0XDY5	E3 ubiquitin protein ligase.	Uncharacterized protein.	0.737
BRE1B-2	MA16_Dca019121	A0A2I0XJK2	A0A2I0W5C5	E3 ubiquitin protein ligase.	Histone H2B.2; Belongs to the histone H2B family.	0.696
BRE1B-2	MA16_Dca021212	A0A2I0XJK2	A0A2I0WE18	E3 ubiquitin protein ligase.	Uncharacterized protein.	0.761
BRE1B-2	MED35C-2	A0A2I0XJK2	A0A2I0X2I6	E3 ubiquitin protein ligase.	Pre-mRNA-processing protein 40C.	0.681
BRE1B-2	UBC1	A0A2I0XJK2	A0A2I0WC71	E3 ubiquitin protein ligase.	Ubiquitin-conjugating enzyme E2 1; Belongs to the ubiquitin-conjugating enzyme family.	0.762
BRE1B-2	UBC2	A0A2I0XJK2	A0A2I0VJG4	E3 ubiquitin protein ligase.	Ubiquitin-conjugating enzyme E2 2.	0.762
BRE1B-2	UBC2-2	A0A2I0XJK2	A0A2I0VT48	E3 ubiquitin protein ligase.	Ubiquitin-conjugating enzyme E2 2.	0.762
BRE1B-2	UBC2-3	A0A2I0XJK2	A0A2I0WEU0	E3 ubiquitin protein ligase.	Ubiquitin-conjugating enzyme E2 2; Belongs to the ubiquitin-conjugating enzyme family.	0.762
BRE1B-2	UBC27	A0A2I0XJK2	A0A2I0WQ04	E3 ubiquitin protein ligase.	Ubiquitin-conjugating enzyme E2 27; Belongs to the ubiquitin-conjugating enzyme family.	0.615
MA16_Dca000853	BRE1B-2	A0A2I0WV21	A0A2I0XJK2	Uncharacterized protein.	E3 ubiquitin protein ligase.	0.712
MA16_Dca000853	MA16_Dca001968	A0A2I0WV21	A0A2I0XDY5	Uncharacterized protein.	Uncharacterized protein.	0.998
MA16_Dca000853	MA16_Dca019121	A0A2I0WV21	A0A2I0W5C5	Uncharacterized protein.	Histone H2B.2; Belongs to the histone H2B family.	0.734
MA16_Dca000853	MA16_Dca021212	A0A2I0WV21	A0A2I0WE18	Uncharacterized protein.	Uncharacterized protein.	0.998
MA16_Dca000853	MED35C-2	A0A2I0WV21	A0A2I0X2I6	Uncharacterized protein.	Pre-mRNA-processing protein 40C.	0.666
MA16_Dca000853	UBC1	A0A2I0WV21	A0A2I0WC71	Uncharacterized protein.	Ubiquitin-conjugating enzyme E2 1; Belongs to the ubiquitin-conjugating enzyme family.	0.622
MA16_Dca000853	UBC2	A0A2I0WV21	A0A2I0VJG4	Uncharacterized protein.	Ubiquitin-conjugating enzyme E2 2.	0.622
MA16_Dca000853	UBC2-2	A0A2I0WV21	A0A2I0VT48	Uncharacterized protein.	Ubiquitin-conjugating enzyme E2 2.	0.622
MA16_Dca000853	UBC2-3	A0A2I0WV21	A0A2I0WEU0	Uncharacterized protein.	Ubiquitin-conjugating enzyme E2 2; Belongs to the ubiquitin-conjugating enzyme family.	0.622
MA16_Dca001968	BRE1B-2	A0A2I0XDY5	A0A2I0XJK2	Uncharacterized protein.	E3 ubiquitin protein ligase.	0.737

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.901

expected number of edges:

28

PPI enrichment p-value:

0.000165

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031398

Positive regulation of protein ubiquitination

5 of 12

2.94

5.24

1.84e-10

GO:1905786

Positive regulation of anaphase-promoting complex-dependent catabolic process

4 of 4

3.32

4.94

1.04e-09

GO:1901987

Regulation of cell cycle phase transition

6 of 88

2.15

4.16

1.04e-09

GO:0031145

Anaphase-promoting complex-dependent catabolic process

4 of 16

2.72

4.07

2.25e-08

GO:0010564

Regulation of cell cycle process

7 of 160

1.96

3.98

2.61e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990757

Ubiquitin ligase activator activity

4 of 4

3.32

4.69

3.06e-09

GO:0010997

Anaphase-promoting complex binding

4 of 4

3.32

4.69

3.06e-09

GO:0044877

Protein-containing complex binding

5 of 201

1.72

2.16

7.50e-06

GO:0004672

Protein kinase activity

4 of 431

1.29

0.89

0.0064

GO:0140096

Catalytic activity, acting on a protein

5 of 1397

0.87

0.5

0.0336

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005680

Anaphase-promoting complex

4 of 16

2.72

3.72

1.11e-07

GO:0000776

Kinetochore

4 of 45

2.27

2.93

1.61e-06

GO:0005815

Microtubule organizing center

3 of 78

1.91

1.64

0.00046

GO:0072686

Mitotic spindle

2 of 21

2.3

1.4

0.0024

GO:0005816

Spindle pole body

2 of 41

2.01

1.14

0.0066

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2484

Anaphase-promoting complex, and Inactivation of APC/C via direct inhibition of the APC/C complex

8 of 28

2.78

8.78

6.03e-18

CL:2486

Anaphase-promoting complex, and Inactivation of APC/C via direct inhibition of the APC/C complex

7 of 22

2.82

8.01

3.58e-16

CL:2488

Anaphase-promoting complex, and Mitotic checkpoint complex

4 of 17

2.69

3.86

5.69e-08

CL:2512

Mitotic checkpoint complex, and Mad3/Bub1 homology region 1

3 of 5

3.1

3.23

1.34e-06

CL:14564

Cohesin complex, and Meiotic spindle

2 of 10

2.62

1.34

0.0036

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04113

Meiosis - yeast

7 of 135

2.04

4.66

6.95e-12

map04111

Cell cycle - yeast

9 of 267

1.85

4.62

3.56e-14

map04120

Ubiquitin mediated proteolysis

4 of 198

1.63

1.72

8.87e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-176408

Regulation of APC/C activators between G1/S and early anaphase

5 of 18

2.76

5.07

2.68e-10

MAP-453276

Regulation of mitotic cell cycle

5 of 27

2.59

4.71

8.02e-10

MAP-174143

APC/C-mediated degradation of cell cycle proteins

5 of 27

2.59

4.71

8.02e-10

MAP-141430

Inactivation of APC/C via direct inhibition of the APC/C complex

3 of 6

3.02

3.27

1.06e-06

MAP-141405

Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

3 of 6

3.02

3.27

1.06e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0033597

Mitotic checkpoint complex

4 of 4

3.32

4.79

2.00e-09

GOCC:0015630

Microtubule cytoskeleton

4 of 130

1.81

1.76

0.00018

GOCC:0005819

Spindle

2 of 41

2.01

0.71

0.0470

GOCC:0110165

Cellular anatomical entity

11 of 10647

0.33

0.25

0.0470

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

4 of 149

1.75

1.76

0.00014

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033010

The WD repeat Cdc20/Fizzy family

4 of 4

3.32

4.52

6.29e-09

IPR015661

Mitotic spindle checkpoint protein Bub1/Mad3

2 of 2

3.32

1.59

0.0014

IPR013212

Mad3/Bub1 homology region 1

2 of 2

3.32

1.59

0.0014

IPR001680

WD40 repeat

4 of 164

1.71

1.35

0.0014

IPR015943

WD40/YVTN repeat-like-containing domain superfamily

4 of 202

1.62

1.3

0.0014

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00777

Mad3/BUB1 hoMad3/BUB1 homology region 1

2 of 2

3.32

1.9

0.00038

SM00320

WD40 repeats

4 of 174

1.68

1.55

0.00038

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