STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (260 aa)    
Predicted Functional Partners:
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
 
 0.992
dapL
LL-diaminopimelate aminotransferase apoenzyme; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate.
 
  
 0.900
EIC01976.1
Aspartate kinase; Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, NAD binding domain; Homoserine dehydrogenase; ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase; COGs: COG0527 Aspartokinase; InterPro IPR011147:IPR001048:IPR002912:IPR005106:IPR001342:IPR0013 41; KEGG: ypb:YPTS_0626 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: homoserine dehydrogenase; aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; SPTR: Bifunctional ThrA; aspartokinase I and homoserine dehydrogenase I (C-termin [...]
 
 
 0.862
EIC03081.1
Aspartate kinase; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase; COGs: COG0527 Aspartokinase; InterPro IPR001341:IPR001048:IPR002912:IPR018042; KEGG: osa:4342980 hypothetical protein; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; PRIAM: Aspartate kinase; SPTR: Aspartokinase; TIGRFAM: aspartate kinase.
 
 
 0.859
EIC01998.1
PFAM: Semialdehyde dehydrogenase, dimerisation domain; Semialdehyde dehydrogenase, NAD binding domain; TIGRFAM: aspartate-semialdehyde dehydrogenase (non-peptidoglycan organisms); COGs: COG0136 Aspartate-semialdehyde dehydrogenase; InterPro IPR012080:IPR000319:IPR000534:IPR012280:IPR005676; KEGG: cpy:Cphy_0426 aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase dimerisation region; Semialdehyde dehydrogenase NAD - binding; PRIAM: Aspartate-semialdehyde dehydrogenase; SPTR: Aspartate-semialdehyde dehydrogenase; TIGRFAM: aspartate-semialdehyde dehydrogenase; Belongs to [...]
 
  
 0.806
EIC00784.1
Polynucleotide adenylyltransferase region; PFAM: HD domain; Poly A polymerase head domain; COGs: COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; InterPro IPR002646; KEGG: tde:TDE1033 polyA polymerase family protein; PFAM: Polynucleotide adenylyltransferase region; SPTR: tRNA adenylyltransferase.
  
    0.804
EIC01235.1
PFAM: Poly A polymerase head domain; TIGRFAM: poly(A) polymerase; COGs: COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; InterPro IPR010206:IPR002646; KEGG: tde:TDE1726 polyA polymerase family protein; PFAM: Polynucleotide adenylyltransferase region; SPTR: PolyA polymerase family protein; TIGRFAM: poly(A) polymerase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
  
    0.804
lysA
Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.
 
 
 0.747
birA
biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
  
 0.722
EIC01222.1
Orn/DAP/Arg decarboxylase 2; PFAM: Pyridoxal-dependent decarboxylase, C-terminal sheet domain; Pyridoxal-dependent decarboxylase, pyridoxal binding domain; COGs: COG0019 Diaminopimelate decarboxylase; InterPro IPR000183; KEGG: gpb:HDN1F_27300 hypothetical protein; PFAM: Orn/DAP/Arg decarboxylase 2; SPTR: Putative pyridoxal-dependent decarboxylase, pyridoxal binding domain protein.
 
 
 0.721
Your Current Organism:
Treponema saccharophilum
NCBI taxonomy Id: 907348
Other names: T. saccharophilum DSM 2985, Treponema saccharophilum DSM 2985, Treponema saccharophilum str. DSM 2985, Treponema saccharophilum strain DSM 2985
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