STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucCSuccinyl-CoA ligase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)    
Predicted Functional Partners:
sucD
Succinyl-CoA ligase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.999
UO65_3195
Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex; 2-oxoglutarate dehydrogenase E1 component.
 0.996
UO65_3280
Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex.
 0.986
UO65_5688
Citrate synthase (si); Belongs to the citrate synthase family.
 
 0.986
UO65_3985
Succinate dehydrogenase cytochrome b-556 subunit.
  
 
 0.984
UO65_5676
Citrate synthase (si); Belongs to the citrate synthase family.
  
 0.982
UO65_3984
Succinate dehydrogenase hydrophobic membrane anchor protein.
  
 
 0.981
UO65_3983
Succinate dehydrogenase flavoprotein subunit.
 0.973
UO65_0249
Succinate dehydrogenase iron-sulfur protein.
 
 0.972
UO65_6363
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.
 0.972
Your Current Organism:
Actinokineospora spheciospongiae
NCBI taxonomy Id: 909613
Other names: A. spheciospongiae, Actinokineospora sp. EG49, Actinokineospora spheciospongiae Kampfer et al. 2015 emend. Nouioui et al. 2018, CCM 8480, DSM 45935, LMG 27700, LMG:27700, strain EG49
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