UO65_5792 protein (Actinokineospora spheciospongiae)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

UO65_5792

Multi-component regulatory system-6. (183 aa)

Predicted Functional Partners:

UO65_5793

0.977

UO65_5791

0.957

UO65_5790

0.913

UO65_5976

0.906

UO65_4466

0.825

UO65_5973

0.825

UO65_4467

0.819

UO65_5974

0.819

UO65_0769

0.808

UO65_0766

0.803

Your Current Organism:

Actinokineospora spheciospongiae

NCBI taxonomy Id: 909613
Other names: A. spheciospongiae, Actinokineospora sp. EG49, Actinokineospora spheciospongiae Kampfer et al. 2015 emend. Nouioui et al. 2018, CCM 8480, DSM 45935, LMG 27700, LMG:27700, strain EG49

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
UO65_0766	UO65_0769	Putative ATP/GTP-binding protein.	Membrane protein.	0.885
UO65_0766	UO65_4466	Putative ATP/GTP-binding protein.	Signal transduction histidine kinase.	0.796
UO65_0766	UO65_4467	Putative ATP/GTP-binding protein.	Hypothetical protein.	0.973
UO65_0766	UO65_5790	Putative ATP/GTP-binding protein.	Putative sensor-like histidine kinase.	0.772
UO65_0766	UO65_5791	Putative ATP/GTP-binding protein.	Hypothetical protein.	0.973
UO65_0766	UO65_5792	Putative ATP/GTP-binding protein.	Multi-component regulatory system-6.	0.803
UO65_0766	UO65_5973	Putative ATP/GTP-binding protein.	Signal transduction histidine kinase.	0.793
UO65_0766	UO65_5974	Putative ATP/GTP-binding protein.	Hypothetical protein; FIG01121836.	0.973
UO65_0769	UO65_0766	Membrane protein.	Putative ATP/GTP-binding protein.	0.885
UO65_0769	UO65_4467	Membrane protein.	Hypothetical protein.	0.797
UO65_0769	UO65_5790	Membrane protein.	Putative sensor-like histidine kinase.	0.459
UO65_0769	UO65_5791	Membrane protein.	Hypothetical protein.	0.802
UO65_0769	UO65_5792	Membrane protein.	Multi-component regulatory system-6.	0.808
UO65_0769	UO65_5793	Membrane protein.	Putative ATP/GTP-binding protein.	0.781
UO65_0769	UO65_5974	Membrane protein.	Hypothetical protein; FIG01121836.	0.803
UO65_0769	UO65_5976	Membrane protein.	Putative ATP/GTP-binding protein.	0.786
UO65_4466	UO65_0766	Signal transduction histidine kinase.	Putative ATP/GTP-binding protein.	0.796
UO65_4466	UO65_4467	Signal transduction histidine kinase.	Hypothetical protein.	0.953
UO65_4466	UO65_5790	Signal transduction histidine kinase.	Putative sensor-like histidine kinase.	0.456
UO65_4466	UO65_5791	Signal transduction histidine kinase.	Hypothetical protein.	0.803

page 1 of 5

Network Stats

number of nodes:

7

number of edges:

21

average node degree:

6

avg. local clustering coefficient:

1

expected number of edges:

7

PPI enrichment p-value:

6.46e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016079

Synaptic vesicle exocytosis

3 of 14

2.89

2.81

3.61e-05

GO:0006887

Exocytosis

4 of 92

2.2

2.58

3.61e-05

GO:0048791

Calcium ion-regulated exocytosis of neurotransmitter

2 of 3

3.39

2.33

0.00024

GO:0016192

Vesicle-mediated transport

5 of 664

1.44

1.6

0.00011

GO:0140029

Exocytic process

2 of 30

2.39

1.33

0.0074

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019905

Syntaxin binding

3 of 37

2.47

2.2

0.00027

GO:0005484

SNAP receptor activity

2 of 40

2.26

0.88

0.0403

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098793

Presynapse

5 of 109

2.22

4.07

3.57e-08

GO:0008021

Synaptic vesicle

3 of 46

2.38

2.54

6.10e-05

GO:0070161

Anchoring junction

4 of 281

1.72

1.95

0.00011

GO:0030672

Synaptic vesicle membrane

2 of 21

2.54

1.71

0.0019

GO:0031201

SNARE complex

2 of 43

2.23

1.36

0.0061

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:26734

Norepinephrine Neurotransmitter Release Cycle, and Rim-like

3 of 10

3.04

3.08

1.42e-05

CL:26699

Mixed, incl. Organic anion transporters, and Regulated exocytosis

4 of 94

2.19

2.78

1.42e-05

CL:6761

SNARE complex disassembly, and Other interleukin signaling

2 of 6

3.08

2.15

0.00044

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04130

SNARE interactions in vesicular transport

2 of 56

2.11

1.09

0.0167

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-449836

Other interleukin signaling

2 of 8

2.96

1.61

0.0031

MAP-181429

Serotonin Neurotransmitter Release Cycle

2 of 7

3.02

1.61

0.0031

MAP-212676

Dopamine Neurotransmitter Release Cycle

2 of 11

2.82

1.6

0.0031

MAP-210500

Glutamate Neurotransmitter Release Cycle

2 of 11

2.82

1.6

0.0031

MAP-181430

Norepinephrine Neurotransmitter Release Cycle

2 of 9

2.91

1.6

0.0031

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098793

Presynapse

5 of 68

2.43

4.8

4.28e-09

GOCC:0045202

Synapse

6 of 249

1.94

3.88

4.28e-09

GOCC:0030672

Synaptic vesicle membrane

3 of 19

2.76

3.26

5.98e-06

GOCC:0048788

Cytoskeleton of presynaptic active zone

2 of 5

3.16

2.42

0.00017

GOCC:0031410

Cytoplasmic vesicle

4 of 672

1.34

1.21

0.0012

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039032

Rim-like

2 of 3

3.39

1.61

0.0032

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