STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UO65_5861Methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (171 aa)    
Predicted Functional Partners:
UO65_5860
Methylated-DNA--protein-cysteine methyltransferase.
 
 0.963
UO65_1913
Methylated-DNA--protein-cysteine methyltransferase.
 
 
 0.794
UO65_3148
Methylated-DNA--protein-cysteine methyltransferase.
 
 0.766
UO65_3500
DNA-3-methyladenine glycosylase.
     0.736
UO65_6097
Hypothetical protein.
 
      0.611
UO65_5859
Uncharacterized protein family UPF0157; COG2320.
 
     0.589
UO65_3521
Methylated-DNA--protein-cysteine methyltransferase.
 
  
0.460
UO65_2416
Hypothetical protein.
   
    0.459
UO65_3105
Universal stress protein UspA.
   
    0.459
UO65_3470
Transcriptional regulator.
   
    0.459
Your Current Organism:
Actinokineospora spheciospongiae
NCBI taxonomy Id: 909613
Other names: A. spheciospongiae, Actinokineospora sp. EG49, Actinokineospora spheciospongiae Kampfer et al. 2015 emend. Nouioui et al. 2018, CCM 8480, DSM 45935, LMG 27700, LMG:27700, strain EG49
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