Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TOPBP1Topoisomerase (DNA) II binding protein 1. (1514 aa)    
Predicted Functional Partners:
BRIP1
Fanconi anemia group J protein isoform X1.
   
 0.994
BRCA1
Breast cancer type 1 susceptibility protein isoform X2.
   
 0.992
TICRR
LOW QUALITY PROTEIN: treslin.
    
 
 0.991
RHNO1
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1.
    
 0.990
BARD1
BRCA1-associated RING domain protein 1 isoform X1.
   
 0.989
ATR
Serine/threonine-protein kinase ATR.
    
 0.986
ATRIP
ATR-interacting protein isoform X2.
    
 0.984
CLSPN
Claspin.
   
 0.981
RAD17
Cell cycle checkpoint protein RAD17 isoform X2.
   
 0.962
E2F1
E2F transcription factor 1.
    
 
 0.958
Your Current Organism:
Serinus canaria
NCBI taxonomy Id: 9135
Other names: Atlantic canary, Canario raza, Common canary, S. canaria, Serinus canarius, canary
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