Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
E2F5E2F transcription factor 5. (346 aa)    
Predicted Functional Partners:
RBL2
Retinoblastoma-like protein 2.
   
 0.987
RBL1
Retinoblastoma-like protein 1 isoform X1.
   
 0.987
TFDP2
Transcription factor Dp-2 isoform X1.
   
 0.983
RB1
Retinoblastoma-associated protein.
   
 0.983
TFDP1
Transcription factor Dp-1 isoform X1.
   
 0.979
SMAD4
SMAD family member 4.
    
 0.965
SMAD3
Mothers against decapentaplegic homolog 3 isoform X1.
    
 0.949
LOC103824734
Mothers against decapentaplegic homolog 2-like isoform X1.
    
 0.949
SMAD2
Mothers against decapentaplegic homolog 2 isoform X1.
    
 0.949
LIN9
Protein lin-9 homolog.
    
 0.911
Your Current Organism:
Serinus canaria
NCBI taxonomy Id: 9135
Other names: Atlantic canary, Canario raza, Common canary, S. canaria, Serinus canarius, canary
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