Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CASP8-2Caspase-8 isoform X1. (459 aa)    
Predicted Functional Partners:
FADD
FAS-associated death domain protein.
   
 0.997
RIPK1
Receptor-interacting serine/threonine-protein kinase 1.
   
 0.994
TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein.
   
 0.993
CFLAR
CASP8 and FADD-like apoptosis regulator.
   
0.989
BID
BH3 interacting domain death agonist.
   
 0.981
CASP3
Caspase-3 isoform X1.
   
0.981
CASP7
Caspase 7.
   
0.970
CASP6
Caspase-6 isoform X2.
   
0.969
LOC103821978
Mucosa-associated lymphoid tissue lymphoma translocation protein 1-like.
    
 0.945
MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1.
    
 0.945
Your Current Organism:
Serinus canaria
NCBI taxonomy Id: 9135
Other names: Atlantic canary, Canario raza, Common canary, S. canaria, Serinus canarius, canary
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