Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CHEK2Serine/threonine-protein kinase CHEK2. (531 aa)    
Predicted Functional Partners:
ATM
Serine-protein kinase ATM isoform X1.
    
 0.999
CDC25A
M-phase inducer phosphatase 1 isoform X1.
   
 0.998
ATR
Serine/threonine-protein kinase ATR.
    
 0.996
BRCA1
Breast cancer type 1 susceptibility protein isoform X2.
   
 0.992
CHEK1
Serine/threonine-protein kinase CHEK1.
   
0.992
MDM2
E3 ubiquitin-protein ligase Mdm2.
    
 0.968
TP53BP1
Tumor suppressor p53-binding protein 1.
    
 0.956
PRKDC
DNA-dependent protein kinase catalytic subunit isoform X1.
    
 
 0.942
BARD1
BRCA1-associated RING domain protein 1 isoform X1.
   
 0.930
RAD52
DNA repair and recombination protein RAD52.
    
 
 0.903
Your Current Organism:
Serinus canaria
NCBI taxonomy Id: 9135
Other names: Atlantic canary, Canario raza, Common canary, S. canaria, Serinus canarius, canary
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