STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDP42662.1Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (557 aa)    
Predicted Functional Partners:
SDP33405.1
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.939
leuC
3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
  
 0.938
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
  
 0.926
SDP21199.1
3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Belongs to the LeuD family.
 
  
 0.920
SDO82220.1
Acetolactate synthase, small subunit.
 
 0.897
SDO82254.1
Acetolactate synthase, large subunit.
 
 0.894
SDP56689.1
Acetolactate synthase, large subunit.
 
 0.893
SDP59519.1
Branched chain amino acid aminotransferase apoenzyme.
  
 0.882
SDO73068.1
Branched-chain amino acid aminotransferase.
  
 0.872
SDP22601.1
(R)-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.867
Your Current Organism:
Desulforhopalus singaporensis
NCBI taxonomy Id: 91360
Other names: D. singaporensis, DSM 12130, Desulforhopalus singaporensis Lie et al. 2000, strain Spore T1
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