SDP47584.1 protein (Desulforhopalus singaporensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

SDP47584.1

Hypothetical protein. (199 aa)

Predicted Functional Partners:

SDP77490.1

0.775

SDP79850.1

0.775

SDP74334.1

0.765

SDP79555.1

0.728

SDP80946.1

0.717

SDP74230.1

0.684

SDP77411.1

0.638

SDO67689.1

0.593

rpoA

0.562

rpoZ

0.548

Your Current Organism:

Desulforhopalus singaporensis

NCBI taxonomy Id: 91360
Other names: D. singaporensis, DSM 12130, Desulforhopalus singaporensis Lie et al. 2000, strain Spore T1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SDO67689.1	SDP47584.1	SAMN05660330_00806	SAMN05660330_02895	Protein of unknown function.	Hypothetical protein.	0.593
SDO67689.1	SDP74230.1	SAMN05660330_00806	SAMN05660330_03905	Protein of unknown function.	Tetratricopeptide repeat-containing protein.	0.418
SDO67689.1	SDP74334.1	SAMN05660330_00806	SAMN05660330_03911	Protein of unknown function.	Arylsulfatase.	0.570
SDO67689.1	SDP77490.1	SAMN05660330_00806	SAMN05660330_04058	Protein of unknown function.	Arylsulfatase.	0.751
SDO67689.1	SDP79850.1	SAMN05660330_00806	SAMN05660330_04156	Protein of unknown function.	Arylsulfatase.	0.673
SDP47584.1	SDO67689.1	SAMN05660330_02895	SAMN05660330_00806	Hypothetical protein.	Protein of unknown function.	0.593
SDP47584.1	SDP74230.1	SAMN05660330_02895	SAMN05660330_03905	Hypothetical protein.	Tetratricopeptide repeat-containing protein.	0.684
SDP47584.1	SDP74334.1	SAMN05660330_02895	SAMN05660330_03911	Hypothetical protein.	Arylsulfatase.	0.765
SDP47584.1	SDP77411.1	SAMN05660330_02895	SAMN05660330_04053	Hypothetical protein.	Protein of unknown function.	0.638
SDP47584.1	SDP77490.1	SAMN05660330_02895	SAMN05660330_04058	Hypothetical protein.	Arylsulfatase.	0.775
SDP47584.1	SDP79555.1	SAMN05660330_02895	SAMN05660330_04143	Hypothetical protein.	Uncharacterized protein.	0.728
SDP47584.1	SDP79850.1	SAMN05660330_02895	SAMN05660330_04156	Hypothetical protein.	Arylsulfatase.	0.775
SDP47584.1	SDP80946.1	SAMN05660330_02895	SAMN05660330_04200	Hypothetical protein.	Uncharacterized protein.	0.717
SDP47584.1	rpoA	SAMN05660330_02895	SAMN05660330_02273	Hypothetical protein.	DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.562
SDP47584.1	rpoZ	SAMN05660330_02895	SAMN05660330_02050	Hypothetical protein.	DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	0.548
SDP74230.1	SDO67689.1	SAMN05660330_03905	SAMN05660330_00806	Tetratricopeptide repeat-containing protein.	Protein of unknown function.	0.418
SDP74230.1	SDP47584.1	SAMN05660330_03905	SAMN05660330_02895	Tetratricopeptide repeat-containing protein.	Hypothetical protein.	0.684
SDP74230.1	SDP74334.1	SAMN05660330_03905	SAMN05660330_03911	Tetratricopeptide repeat-containing protein.	Arylsulfatase.	0.754
SDP74230.1	SDP77411.1	SAMN05660330_03905	SAMN05660330_04053	Tetratricopeptide repeat-containing protein.	Protein of unknown function.	0.620
SDP74230.1	SDP77490.1	SAMN05660330_03905	SAMN05660330_04058	Tetratricopeptide repeat-containing protein.	Arylsulfatase.	0.783

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.751

expected number of edges:

12

PPI enrichment p-value:

1.48e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006560

Proline metabolic process

6 of 13

2.71

5.87

5.21e-12

GO:0009064

Glutamine family amino acid metabolic process

8 of 71

2.09

5.04

1.35e-12

GO:0010133

Proline catabolic process to glutamate

4 of 4

3.04

4.16

2.35e-08

GO:0006536

Glutamate metabolic process

5 of 30

2.26

3.64

4.15e-08

GO:0009084

Glutamine family amino acid biosynthetic process

4 of 22

2.3

2.87

2.48e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004657

Proline dehydrogenase activity

2 of 2

3.04

1.19

0.0073

GO:0003842

1-pyrroline-5-carboxylate dehydrogenase activity

2 of 2

3.04

1.19

0.0073

GO:0016620

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

3 of 59

1.75

0.98

0.0110

GO:0003824

Catalytic activity

11 of 5229

0.36

0.27

0.0322

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005739

Mitochondrion

7 of 1098

0.85

0.57

0.0106

GO:0005737

Cytoplasm

11 of 5177

0.37

0.26

0.0383

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13004

Glutamate and glutamine metabolism, and Proline catabolism

9 of 16

2.79

10.23

5.11e-21

CL:13006

Glutamate biosynthetic process, and Proline metabolic process

8 of 11

2.9

9.59

3.27e-19

CL:12928

Mixed, incl. Glutamine family amino acid metabolic process, and Glutamate and glutamine metabolism

11 of 74

2.21

8.15

2.20e-21

CL:13008

Oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor, and Glutamine synthetase, catalytic domain

4 of 6

2.86

4.2

1.62e-08

CL:13061

Pyrroline-5-carboxylate reductase, and Proline metabolism

2 of 5

2.64

1.38

0.0030

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00250

Alanine, aspartate and glutamate metabolism

6 of 74

1.95

3.56

4.75e-09

map00330

Arginine and proline metabolism

6 of 142

1.67

2.61

1.02e-07

map00910

Nitrogen metabolism

4 of 65

1.83

2.22

1.19e-05

map00332

Carbapenem biosynthesis

2 of 3

2.86

2.08

0.00016

map00220

Arginine biosynthesis

3 of 33

2.0

1.97

0.00010

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70688

Proline catabolism

4 of 4

3.04

4.37

9.73e-09

MAP-8964539

Glutamate and glutamine metabolism

5 of 23

2.38

4.03

9.73e-09

MAP-389661

Glyoxylate metabolism and glycine degradation

4 of 53

1.92

2.12

3.33e-05

MAP-71291

Metabolism of amino acids and derivatives

9 of 459

1.33

2.02

8.62e-09

MAP-112315

Transmission across Chemical Synapses

3 of 74

1.65

1.06

0.0061

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005739

Mitochondrion

6 of 857

0.89

0.48

0.0437

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0642

Proline metabolism

3 of 3

3.04

3.06

2.72e-06

KW-0560

Oxidoreductase

4 of 350

1.1

0.63

0.0246

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00171

Aldehyde dehydrogenase family

3 of 44

1.87

1.04

0.0094

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036651

Glutamine synthetase, N-terminal domain superfamily

3 of 3

3.04

2.47

3.26e-05

IPR008146

Glutamine synthetase, catalytic domain

3 of 3

3.04

2.47

3.26e-05

IPR014746

Glutamine synthetase/guanido kinase, catalytic domain

3 of 6

2.74

2.36

4.56e-05

IPR005931

Delta-1-pyrroline-5-carboxylate dehydrogenase

2 of 2

3.04

1.37

0.0033

IPR016163

Aldehyde dehydrogenase, C-terminal

3 of 46

1.86

1.13

0.0059

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01230

Glutamine synthetase, catalytic domain

3 of 3

3.04

2.99

3.58e-06

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