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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STAT3Signal transducer and activator of transcription 3 isoform X1. (771 aa)    
Predicted Functional Partners:
JAK1
Tyrosine-protein kinase JAK1.
   
 0.985
JAK2
Tyrosine-protein kinase JAK2 isoform X1.
   
 0.982
EP300
Histone acetyltransferase p300 isoform X1.
    
 0.948
FOXO1
Forkhead box protein O1.
   
 0.928
FOXO3
Forkhead box protein O3.
   
 0.928
FOXO6
Forkhead box protein O6.
   
 0.913
FOXO4
Forkhead box protein O4.
   
 0.913
SOCS3
Suppressor of cytokine signaling 3.
   
 0.896
CREBBP
CREB-binding protein isoform X1.
    
 0.872
MET
Hepatocyte growth factor receptor isoform X1.
   
 0.848
Your Current Organism:
Parus major
NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.