Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
PLEKPleckstrin isoform X1. (353 aa)    
Predicted Functional Partners:
MCF2
Guanine nucleotide exchange factor MCF2.
      
 0.872
CNN2
Calponin-2.
     
 0.705
RABIF
Guanine nucleotide exchange factor MSS4.
      
 0.650
CDC42
Cell division control protein 42 homolog isoform X1.
   
 
 0.648
PIK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform.
   
  
 0.575
INPP5B
Type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1.
   
 
 0.562
RASA1
Ras GTPase-activating protein 1.
   
  
 0.553
PHLPP1
PH domain and leucine-rich repeat-containing protein phosphatase.
      
 0.540
PLEKHA3
Pleckstrin homology domain-containing family A member 3.
      
 0.540
SYNJ1
Synaptojanin-1 isoform X1.
      
 0.537
Your Current Organism:
Parus major
NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major
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