close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SYKTyrosine-protein kinase SYK. (635 aa)    
Predicted Functional Partners:
PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2.
   
0.986
CBLB
E3 ubiquitin-protein ligase CBL-B isoform X1.
    
 0.977
CARD9
Caspase recruitment domain-containing protein 9 isoform X1.
   
 
 0.967
PTPN11
Tyrosine-protein phosphatase non-receptor type 11 isoform X1.
   
0.962
CD3E
CD3e molecule.
   
 0.955
CD247
LOW QUALITY PROTEIN: T-cell surface glycoprotein CD3 zeta chain.
   
 0.937
LCP2
Lymphocyte cytosolic protein 2.
   
 0.902
PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1.
   
0.871
LYN
Tyrosine-protein kinase Lyn isoform X1.
   
0.854
VAV2
Guanine nucleotide exchange factor VAV2 isoform X1.
   
 0.846
Your Current Organism:
Parus major
NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major
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