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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GUCY2CGuanylate cyclase 2C. (1022 aa)    
Predicted Functional Partners:
GUCA2B
Guanylin-like.
   
 
 0.874
NPPC
Natriuretic peptide C.
    
 0.744
PDZD3
PDZ domain containing 3.
    
 
 0.555
GTF3C6
General transcription factor 3C polypeptide 6 isoform X1.
      
 0.544
GAK
Cyclin-G-associated kinase isoform X1.
      
 0.538
NPPB
Natriuretic peptides A.
    
 0.527
GUCA1A
Guanylyl cyclase-activating protein 1 isoform X1.
    
 0.474
PDE10A
CAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1.
   
 0.433
PDE6C
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha.
   
 0.428
CFTR
Cystic fibrosis transmembrane conductance regulator isoform X1.
      
 0.420
Your Current Organism:
Parus major
NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.