close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SREBF2Sterol regulatory element-binding transcription factor 2. (1116 aa)    
Predicted Functional Partners:
SCAP
Sterol regulatory element-binding protein cleavage-activating protein isoform X1.
   
 0.941
NPC1
Niemann-Pick C1 protein.
   
 0.854
KPNB1
Importin subunit beta-1 isoform X1.
    
 0.790
MBTPS2
Membrane-bound transcription factor site-2 protease isoform X1.
    
 0.757
MBTPS1
Membrane-bound transcription factor site-1 protease isoform X1.
     
 0.688
HMGCR
3-hydroxy-3-methylglutaryl-Coenzyme A reductase.
     
 0.608
EP300
Histone acetyltransferase p300 isoform X1.
    
 0.559
MED15
Mediator complex subunit 15.
    
 
 0.538
MED15-2
Mediator of RNA polymerase II transcription subunit 15.
    
 
 0.538
CREBBP
CREB-binding protein isoform X1.
    
 0.497
Your Current Organism:
Parus major
NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.