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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDK4Cyclin-dependent kinase 4-like. (210 aa)    
Predicted Functional Partners:
CCND1
G1/S-specific cyclin-D1 isoform X1.
   
 0.949
CCNA2
Cyclin-A2 isoform X1.
   
 0.918
CCNB2
G2/mitotic-specific cyclin-B2.
   
 0.898
CCNA1
Cyclin-A1.
   
 0.881
CCND2
G1/S-specific cyclin-D2 isoform X1.
   
 0.865
CDKN2C
Cyclin-dependent kinase 4 inhibitor C.
   
 0.852
RB1
Retinoblastoma-associated protein isoform X1.
   
 0.851
CCNE1
G1/S-specific cyclin-E1.
   
 0.846
CDC6
Cell division control protein 6 homolog isoform X1.
   
 0.827
CDC25A
M-phase inducer phosphatase 1 isoform X1.
   
 0.820
Your Current Organism:
Parus major
NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.