close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SOS1Son of sevenless homolog 1 isoform X1. (1265 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor-binding protein 2.
   
 0.999
PTPN11
Tyrosine-protein phosphatase non-receptor type 11 isoform X1.
    
 0.986
EGFR
Epidermal growth factor receptor isoform X1.
    
 0.967
KRAS
GTPase KRas isoform X1.
   
 0.962
NRAS-2
GTPase NRas.
   
 0.962
HRAS
GTPase HRas.
   
 0.954
FGFR4
Fibroblast growth factor receptor 4 isoform X1.
    
 0.952
FGFR3
Fibroblast growth factor receptor 3 isoform X1.
    
 0.951
FGFR2
Fibroblast growth factor receptor 2 isoform X1.
    
 0.944
PTK2
Focal adhesion kinase 1 isoform X1.
    
 0.944
Your Current Organism:
Parus major
NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.