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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PELI2E3 ubiquitin-protein ligase pellino homolog 2 isoform X1. (420 aa)    
Predicted Functional Partners:
UBE2V1
Ubiquitin-conjugating enzyme E2 variant 1.
    
 0.944
IRAK2
Interleukin-1 receptor-associated kinase-like 2 isoform X1.
    
 0.851
IRAK4
Interleukin-1 receptor-associated kinase 4 isoform X1.
    
 0.836
TRAF6
TNF receptor-associated factor 6.
   
 0.778
UBE2N
Ubiquitin-conjugating enzyme E2 N.
    
 0.711
ESPN
Espin.
      
 0.679
GABRE
Gamma-aminobutyric acid receptor subunit epsilon.
      
 0.679
RIPK1
Receptor-interacting serine/threonine-protein kinase 1 isoform X1.
    
 0.668
UBE2V2
Ubiquitin-conjugating enzyme E2 variant 2 isoform X1.
    
 0.516
MYD88
Myeloid differentiation primary response protein MyD88.
    
 
 0.508
Your Current Organism:
Parus major
NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.