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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ORAI1Calcium release-activated calcium channel protein 1. (257 aa)    
Predicted Functional Partners:
STIM2
Stromal interaction molecule 2 isoform X1.
    
 0.991
ORAI2
Calcium release-activated calcium channel protein 2.
  
 
0.964
STIM1
Stromal interaction molecule 1.
    
 0.962
TRPC1
Transient receptor potential cation channel subfamily C member 1.
    
 
 0.692
CALML4
Calmodulin-like protein 4.
    
 0.558
GPRIN2
G protein-regulated inducer of neurite outgrowth 2.
      
 0.520
CALML3
Calmodulin, striated muscle.
    
 0.437
CALM2
Calmodulin.
    
 0.437
CALM1
Calmodulin 1.
    
 0.437
NFAT5
Nuclear factor of activated T-cells 5 isoform X1.
   
  
 0.428
Your Current Organism:
Parus major
NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.