close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GRNProgranulin. (409 aa)    
Predicted Functional Partners:
CS
Citrate synthase, mitochondrial.
   
   0.714
C10H15orf40
UPF0235 protein C15orf40 homolog.
    
   0.707
CXorf56
UPF0428 protein CXorf56 homolog.
    
   0.707
POLE2
DNA polymerase epsilon subunit 2.
    
   0.707
SLC25A1
Solute carrier family 25 (mitochondrial citrate transporter), member 1.
    
   0.707
DRG1
Developmentally-regulated GTP-binding protein 1.
    
   0.707
TARDBP
TAR DNA-binding protein 43.
    
 
 0.639
CTSZ
Cathepsin X.
   
 0.625
CTSO
Cathepsin O isoform X1.
   
 0.579
ENSPMJP00000004737
annotation not available
    
 
 0.561
Your Current Organism:
Parus major
NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.