close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
POLE4DNA polymerase epsilon 4, accessory subunit. (143 aa)    
Predicted Functional Partners:
POLE3
DNA polymerase epsilon subunit 3.
    
 0.995
POLE2
DNA polymerase epsilon subunit 2.
    
 0.993
POLE
DNA polymerase epsilon catalytic subunit A.
    
 0.993
WRN
Werner syndrome ATP-dependent helicase isoform X1.
     
 0.929
POLA1
DNA polymerase alpha catalytic subunit isoform X1.
    
 0.921
REV3L
DNA polymerase zeta catalytic subunit.
    
 0.863
CDC45
Cell division control protein 45 homolog.
    
 0.842
POLA2
DNA polymerase alpha subunit B.
     
 0.820
PRIM2
DNA primase large subunit.
     
 0.804
POLD2
DNA polymerase delta 2, accessory subunit.
     
 0.803
Your Current Organism:
Parus major
NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.