Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
POLE4DNA polymerase epsilon 4, accessory subunit. (143 aa)    
Predicted Functional Partners:
POLE2
DNA polymerase epsilon subunit 2.
    
 0.999
POLE3
DNA polymerase epsilon subunit 3.
    
 0.999
POLE
DNA polymerase epsilon catalytic subunit A.
    
 0.999
POLD2
DNA polymerase delta 2, accessory subunit.
     
 0.972
POLD4
DNA polymerase delta subunit 4.
     
  0.927
POLA1
DNA polymerase alpha catalytic subunit isoform X1.
    
 0.921
POLD3
DNA polymerase delta subunit 3 isoform X1.
    
 0.913
NFYB
Nuclear transcription factor Y subunit beta.
    
 
 0.900
PCNA
Proliferating cell nuclear antigen.
   
 0.840
CDC45
Cell division control protein 45 homolog.
    
 0.817
Your Current Organism:
Parus major
NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major
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