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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRAM1PML-RARA-regulated adapter molecule 1 isoform X1. (453 aa)    
Predicted Functional Partners:
NSMCE4A
Non-structural maintenance of chromosomes element 4 homolog A.
   
 0.884
NSMCE1
Non-structural maintenance of chromosomes element 1 homolog isoform X1.
    
 0.881
SMC6
Structural maintenance of chromosomes protein 6.
   
 0.867
SMC5
Structural maintenance of chromosomes protein 5 isoform X1.
   
 0.866
NSMCE2
E3 SUMO-protein ligase NSE2 isoform X1.
    
 0.864
SMC3
Structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6).
    
 0.625
ENSPMJP00000005500
annotation not available
   
 0.571
SMC1B
Structural maintenance of chromosomes protein 1B.
   
 0.571
SMC2
Structural maintenance of chromosomes protein 2.
    
 0.551
SMC4
Structural maintenance of chromosomes protein 4-like isoform X1.
    
 0.551
Your Current Organism:
Parus major
NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.