RHEB protein (Parus major) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

RHEB

GTP-binding protein Rheb isoform X1. (205 aa)

Predicted Functional Partners:

TSC2

0.992

TSC1

0.985

MTOR

0.984

MLST8

0.974

BNIP3

0.932

TBC1D7

0.931

LOC107213149

0.929

DEPTOR

0.924

ITSN2

0.842

RPTOR

0.792

Your Current Organism:

Parus major

NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNIP3	RHEB	ENSPMJP00000007276	ENSPMJP00000005688	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3.	GTP-binding protein Rheb isoform X1.	0.932
DEPTOR	LOC107213149	ENSPMJP00000014838	ENSPMJP00000009059	DEP domain-containing mTOR-interacting protein.	DEP domain-containing mTOR-interacting protein-like isoform X1.	0.901
DEPTOR	MLST8	ENSPMJP00000014838	ENSPMJP00000026335	DEP domain-containing mTOR-interacting protein.	Target of rapamycin complex subunit LST8.	0.950
DEPTOR	MTOR	ENSPMJP00000014838	ENSPMJP00000007249	DEP domain-containing mTOR-interacting protein.	Serine/threonine-protein kinase mTOR isoform X1.	0.987
DEPTOR	RHEB	ENSPMJP00000014838	ENSPMJP00000005688	DEP domain-containing mTOR-interacting protein.	GTP-binding protein Rheb isoform X1.	0.924
DEPTOR	RPTOR	ENSPMJP00000014838	ENSPMJP00000023020	DEP domain-containing mTOR-interacting protein.	Regulatory associated protein of MTOR complex 1.	0.785
ITSN2	RHEB	ENSPMJP00000017200	ENSPMJP00000005688	Intersectin-2 isoform X1.	GTP-binding protein Rheb isoform X1.	0.842
LOC107213149	DEPTOR	ENSPMJP00000009059	ENSPMJP00000014838	DEP domain-containing mTOR-interacting protein-like isoform X1.	DEP domain-containing mTOR-interacting protein.	0.901
LOC107213149	MLST8	ENSPMJP00000009059	ENSPMJP00000026335	DEP domain-containing mTOR-interacting protein-like isoform X1.	Target of rapamycin complex subunit LST8.	0.966
LOC107213149	MTOR	ENSPMJP00000009059	ENSPMJP00000007249	DEP domain-containing mTOR-interacting protein-like isoform X1.	Serine/threonine-protein kinase mTOR isoform X1.	0.987
LOC107213149	RHEB	ENSPMJP00000009059	ENSPMJP00000005688	DEP domain-containing mTOR-interacting protein-like isoform X1.	GTP-binding protein Rheb isoform X1.	0.929
LOC107213149	RPTOR	ENSPMJP00000009059	ENSPMJP00000023020	DEP domain-containing mTOR-interacting protein-like isoform X1.	Regulatory associated protein of MTOR complex 1.	0.774
MLST8	DEPTOR	ENSPMJP00000026335	ENSPMJP00000014838	Target of rapamycin complex subunit LST8.	DEP domain-containing mTOR-interacting protein.	0.950
MLST8	LOC107213149	ENSPMJP00000026335	ENSPMJP00000009059	Target of rapamycin complex subunit LST8.	DEP domain-containing mTOR-interacting protein-like isoform X1.	0.966
MLST8	MTOR	ENSPMJP00000026335	ENSPMJP00000007249	Target of rapamycin complex subunit LST8.	Serine/threonine-protein kinase mTOR isoform X1.	0.999
MLST8	RHEB	ENSPMJP00000026335	ENSPMJP00000005688	Target of rapamycin complex subunit LST8.	GTP-binding protein Rheb isoform X1.	0.974
MLST8	RPTOR	ENSPMJP00000026335	ENSPMJP00000023020	Target of rapamycin complex subunit LST8.	Regulatory associated protein of MTOR complex 1.	0.998
MLST8	TSC1	ENSPMJP00000026335	ENSPMJP00000008212	Target of rapamycin complex subunit LST8.	Tuberous sclerosis 1.	0.782
MLST8	TSC2	ENSPMJP00000026335	ENSPMJP00000026310	Target of rapamycin complex subunit LST8.	Tuberous sclerosis 2.	0.809
MTOR	DEPTOR	ENSPMJP00000007249	ENSPMJP00000014838	Serine/threonine-protein kinase mTOR isoform X1.	DEP domain-containing mTOR-interacting protein.	0.987