close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMC3Structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6). (1217 aa)    
Predicted Functional Partners:
NIPBL
Cohesin loading factor subunit SCC2.
   
 0.998
ESCO1
N-acetyltransferase ESCO1 isoform X1.
   
 0.987
PDS5A
Sister chromatid cohesion protein PDS5 homolog A isoform X1.
   
 0.980
ENSPMJP00000005500
annotation not available
   
0.974
SMC1B
Structural maintenance of chromosomes protein 1B.
   
0.974
RAD21L1
Double-strand-break repair protein rad21-like protein 1.
   
 0.972
RAD21
Double-strand-break repair protein rad21 homolog.
   
 0.972
PDS5B
Sister chromatid cohesion protein PDS5 homolog B isoform X1.
   
 0.971
WAPL
Wings apart-like protein homolog isoform X1.
   
 0.953
STAG2
Cohesin subunit SA-2 isoform X1.
   
 0.949
Your Current Organism:
Parus major
NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.