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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PITRM1Presequence protease, mitochondrial. (940 aa)    
Predicted Functional Partners:
APP
Amyloid beta A4 protein isoform X1.
    
 
 0.865
MIPEP
Mitochondrial intermediate peptidase isoform X1.
    
 
 0.692
HSPD1
60 kDa heat shock protein, mitochondrial.
   
 
  0.613
FXN
Frataxin, mitochondrial isoform X1.
     
 0.613
EPRS1
Bifunctional glutamate/proline--tRNA ligase isoform X1.
  
  
 0.595
ATF6
Activating transcription factor 6.
   
    0.587
ATP5F1B
F-type H+-transporting ATPase subunit beta.
    
  0.571
APLP2
Amyloid-like protein 2 isoform X1.
    
 
 0.571
PDHA1
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform X1.
   
   0.569
METAP1
Methionine aminopeptidase 1.
   
 
 0.566
Your Current Organism:
Parus major
NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.