close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MSH4MutS protein homolog 4 isoform X1. (924 aa)    
Predicted Functional Partners:
MSH5
DNA mismatch repair protein MSH5.
  
0.997
PMS1
PMS1 protein homolog 1 isoform X1.
 
 0.931
PMS2
Mismatch repair endonuclease PMS2.
 
 0.921
MLH1
DNA mismatch repair protein MLH1.
  
 0.908
MLH3
DNA mismatch repair protein Mlh3 isoform X1.
  
 0.908
PCNA
Proliferating cell nuclear antigen.
   
 0.854
ENSPMJP00000018528
annotation not available
    
 
 0.843
FANCM
Fanconi anemia group M protein.
    
 
 0.843
EXO1
Exonuclease 1.
   
 0.833
TOP3A
DNA topoisomerase 3-alpha.
  
 0.812
Your Current Organism:
Parus major
NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.