close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LRP6Low-density lipoprotein receptor-related protein 6 isoform X1. (1433 aa)    
Predicted Functional Partners:
SOST
Sclerostin isoform X1.
    
 0.998
FZD4
Frizzled 4.
    
 0.983
LRP5
Low-density lipoprotein receptor-related protein 5 isoform X1.
  
 
0.982
DKK2
Dickkopf-related protein 2.
    
 0.978
FZD6
Frizzled 6.
    
 0.975
DKK1
Dickkopf WNT signaling pathway inhibitor 1.
    
 0.974
FZD5
Frizzled 5/8.
    
 0.970
WNT1
Wingless-type MMTV integration site family, member 1.
    
 0.958
FZD2
Frizzled 2.
    
 0.948
FZD1
Frizzled 1/7.
    
 0.948
Your Current Organism:
Parus major
NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.