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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTF1APancreas transcription factor 1 subunit alpha. (275 aa)    
Predicted Functional Partners:
RBPJL
Recombining binding protein suppressor of hairless-like protein.
   
 0.722
RBPJ
Recombining binding protein suppressor of hairless isoform X1.
   
 0.721
VSX1
Visual system homeobox protein 1.
   
  
 0.578
INS
Insulin.
   
  
 0.572
FOXN4
Forkhead box protein N4.
   
 
 0.553
PDX1
LOW QUALITY PROTEIN: pancreas/duodenum homeobox protein 1.
   
 
 0.542
NKX6-2
Homeobox protein Nkx-6.2.
      
 0.521
TCF3
Transcription factor 3.
   
 0.512
TCF12
Transcription factor 12 isoform X1.
   
 0.512
HNF1B
Transcription factor 2, hepatocyte nuclear factor 1-beta.
     
 0.470
Your Current Organism:
Parus major
NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.