NSD1 protein (Parus major) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NSD1

Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific isoform X1. (2593 aa)

Predicted Functional Partners:

PLOD2

0.691

CAMKMT

0.672

EED

0.624

KDM5A

0.598

MRE11

0.575

ENSPMJP00000002721

0.574

NUP98

0.555

PRDM2

0.555

BARD1

0.553

KDM6A

0.544

Your Current Organism:

Parus major

NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARD1	ENSPMJP00000002721	ENSPMJP00000008533	ENSPMJP00000002721	BRCA1-associated RING domain protein 1 isoform X1.	annotation not available	0.764
BARD1	MRE11	ENSPMJP00000008533	ENSPMJP00000024289	BRCA1-associated RING domain protein 1 isoform X1.	Double-strand break repair protein MRE11A isoform X1.	0.978
BARD1	NSD1	ENSPMJP00000008533	ENSPMJP00000009256	BRCA1-associated RING domain protein 1 isoform X1.	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific isoform X1.	0.553
CAMKMT	NSD1	ENSPMJP00000019460	ENSPMJP00000009256	Calmodulin-lysine N-methyltransferase isoform X1.	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific isoform X1.	0.672
CAMKMT	PLOD2	ENSPMJP00000019460	ENSPMJP00000025400	Calmodulin-lysine N-methyltransferase isoform X1.	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2.	0.900
CAMKMT	PRDM2	ENSPMJP00000019460	ENSPMJP00000013709	Calmodulin-lysine N-methyltransferase isoform X1.	[histone H3]-lysine9 N-trimethyltransferase PRDM2.	0.716
EED	ENSPMJP00000002721	ENSPMJP00000002219	ENSPMJP00000002721	Polycomb protein EED.	annotation not available	0.765
EED	KDM5A	ENSPMJP00000002219	ENSPMJP00000000132	Polycomb protein EED.	[histone H3]-trimethyl-L-lysine4 demethylase.	0.765
EED	KDM6A	ENSPMJP00000002219	ENSPMJP00000014342	Polycomb protein EED.	Lysine-specific demethylase 6A isoform X1.	0.930
EED	NSD1	ENSPMJP00000002219	ENSPMJP00000009256	Polycomb protein EED.	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific isoform X1.	0.624
ENSPMJP00000002721	BARD1	ENSPMJP00000002721	ENSPMJP00000008533	annotation not available	BRCA1-associated RING domain protein 1 isoform X1.	0.764
ENSPMJP00000002721	EED	ENSPMJP00000002721	ENSPMJP00000002219	annotation not available	Polycomb protein EED.	0.765
ENSPMJP00000002721	KDM5A	ENSPMJP00000002721	ENSPMJP00000000132	annotation not available	[histone H3]-trimethyl-L-lysine4 demethylase.	0.477
ENSPMJP00000002721	KDM6A	ENSPMJP00000002721	ENSPMJP00000014342	annotation not available	Lysine-specific demethylase 6A isoform X1.	0.864
ENSPMJP00000002721	MRE11	ENSPMJP00000002721	ENSPMJP00000024289	annotation not available	Double-strand break repair protein MRE11A isoform X1.	0.717
ENSPMJP00000002721	NSD1	ENSPMJP00000002721	ENSPMJP00000009256	annotation not available	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific isoform X1.	0.574
KDM5A	EED	ENSPMJP00000000132	ENSPMJP00000002219	[histone H3]-trimethyl-L-lysine4 demethylase.	Polycomb protein EED.	0.765
KDM5A	ENSPMJP00000002721	ENSPMJP00000000132	ENSPMJP00000002721	[histone H3]-trimethyl-L-lysine4 demethylase.	annotation not available	0.477
KDM5A	KDM6A	ENSPMJP00000000132	ENSPMJP00000014342	[histone H3]-trimethyl-L-lysine4 demethylase.	Lysine-specific demethylase 6A isoform X1.	0.692
KDM5A	NSD1	ENSPMJP00000000132	ENSPMJP00000009256	[histone H3]-trimethyl-L-lysine4 demethylase.	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific isoform X1.	0.598