VTCN1 protein (Parus major) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

VTCN1

V-set domain-containing T-cell activation inhibitor 1. (270 aa)

Predicted Functional Partners:

CTLA4

0.674

LOC107207627

0.553

CD274

0.541

VPS36

0.527

PDCD1

0.469

HELZ2

0.439

CD276

0.432

UBE2I

0.415

Your Current Organism:

Parus major

NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD274	CTLA4	ENSPMJP00000021849	ENSPMJP00000024926	Programmed cell death 1 ligand 1.	Cytotoxic T-lymphocyte-associated protein 4.	0.695
CD274	LOC107207627	ENSPMJP00000021849	ENSPMJP00000024924	Programmed cell death 1 ligand 1.	Inducible T-cell costimulator-like.	0.645
CD274	PDCD1	ENSPMJP00000021849	ENSPMJP00000026861	Programmed cell death 1 ligand 1.	Programmed cell death protein 1 isoform X1.	0.998
CD274	VTCN1	ENSPMJP00000021849	ENSPMJP00000013654	Programmed cell death 1 ligand 1.	V-set domain-containing T-cell activation inhibitor 1.	0.541
CD276	CTLA4	ENSPMJP00000009453	ENSPMJP00000024926	Immune costimulatory protein B7-H3.	Cytotoxic T-lymphocyte-associated protein 4.	0.755
CD276	LOC107207627	ENSPMJP00000009453	ENSPMJP00000024924	Immune costimulatory protein B7-H3.	Inducible T-cell costimulator-like.	0.533
CD276	VTCN1	ENSPMJP00000009453	ENSPMJP00000013654	Immune costimulatory protein B7-H3.	V-set domain-containing T-cell activation inhibitor 1.	0.432
CTLA4	CD274	ENSPMJP00000024926	ENSPMJP00000021849	Cytotoxic T-lymphocyte-associated protein 4.	Programmed cell death 1 ligand 1.	0.695
CTLA4	CD276	ENSPMJP00000024926	ENSPMJP00000009453	Cytotoxic T-lymphocyte-associated protein 4.	Immune costimulatory protein B7-H3.	0.755
CTLA4	LOC107207627	ENSPMJP00000024926	ENSPMJP00000024924	Cytotoxic T-lymphocyte-associated protein 4.	Inducible T-cell costimulator-like.	0.817
CTLA4	PDCD1	ENSPMJP00000024926	ENSPMJP00000026861	Cytotoxic T-lymphocyte-associated protein 4.	Programmed cell death protein 1 isoform X1.	0.713
CTLA4	VTCN1	ENSPMJP00000024926	ENSPMJP00000013654	Cytotoxic T-lymphocyte-associated protein 4.	V-set domain-containing T-cell activation inhibitor 1.	0.674
HELZ2	VTCN1	ENSPMJP00000008717	ENSPMJP00000013654	Helicase with zinc finger domain 2 isoform X1.	V-set domain-containing T-cell activation inhibitor 1.	0.439
LOC107207627	CD274	ENSPMJP00000024924	ENSPMJP00000021849	Inducible T-cell costimulator-like.	Programmed cell death 1 ligand 1.	0.645
LOC107207627	CD276	ENSPMJP00000024924	ENSPMJP00000009453	Inducible T-cell costimulator-like.	Immune costimulatory protein B7-H3.	0.533
LOC107207627	CTLA4	ENSPMJP00000024924	ENSPMJP00000024926	Inducible T-cell costimulator-like.	Cytotoxic T-lymphocyte-associated protein 4.	0.817
LOC107207627	PDCD1	ENSPMJP00000024924	ENSPMJP00000026861	Inducible T-cell costimulator-like.	Programmed cell death protein 1 isoform X1.	0.662
LOC107207627	VTCN1	ENSPMJP00000024924	ENSPMJP00000013654	Inducible T-cell costimulator-like.	V-set domain-containing T-cell activation inhibitor 1.	0.553
PDCD1	CD274	ENSPMJP00000026861	ENSPMJP00000021849	Programmed cell death protein 1 isoform X1.	Programmed cell death 1 ligand 1.	0.998
PDCD1	CTLA4	ENSPMJP00000026861	ENSPMJP00000024926	Programmed cell death protein 1 isoform X1.	Cytotoxic T-lymphocyte-associated protein 4.	0.713