PV08_10210 protein (Exophiala spinifera) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PV08_10210

Uncharacterized protein. (806 aa)

Predicted Functional Partners:

PV08_01444

0.874

PV08_07511

0.874

PV08_04517

0.869

PV08_01267

0.869

PV08_05777

0.863

PV08_00568

0.863

PV08_01680

0.765

PV08_06373

0.765

PV08_00622

0.765

PV08_00820

0.706

Your Current Organism:

Exophiala spinifera

NCBI taxonomy Id: 91928
Other names: ATCC 18218, CBS 899.68, DUKE 3342, E. spinifera, NCMH 152, NCPF 2358, Phialophora spinifera, Rhinocladiella spinifera

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PV08_00568	PV08_00622	A0A0D2BM57	A0A0D2A5L7	RING-type domain-containing protein.	Uncharacterized protein.	0.963
PV08_00568	PV08_01267	A0A0D2BM57	A0A0D2BQC3	RING-type domain-containing protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.994
PV08_00568	PV08_01444	A0A0D2BM57	A0A0D1YZX0	RING-type domain-containing protein.	PRKCSH domain-containing protein.	0.968
PV08_00568	PV08_01680	A0A0D2BM57	A0A0D1Z0H6	RING-type domain-containing protein.	Cell division control protein 48; Belongs to the AAA ATPase family.	0.988
PV08_00568	PV08_04517	A0A0D2BM57	A0A0D2BFC9	RING-type domain-containing protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.995
PV08_00568	PV08_06373	A0A0D2BM57	A0A0D1ZU51	RING-type domain-containing protein.	AAA domain-containing protein.	0.880
PV08_00568	PV08_07511	A0A0D2BM57	A0A0D1ZPI0	RING-type domain-containing protein.	Uncharacterized protein.	0.968
PV08_00568	PV08_10210	A0A0D2BM57	A0A0D1Y7L8	RING-type domain-containing protein.	Uncharacterized protein.	0.863
PV08_00622	PV08_00568	A0A0D2A5L7	A0A0D2BM57	Uncharacterized protein.	RING-type domain-containing protein.	0.963
PV08_00622	PV08_01267	A0A0D2A5L7	A0A0D2BQC3	Uncharacterized protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.966
PV08_00622	PV08_01444	A0A0D2A5L7	A0A0D1YZX0	Uncharacterized protein.	PRKCSH domain-containing protein.	0.916
PV08_00622	PV08_04517	A0A0D2A5L7	A0A0D2BFC9	Uncharacterized protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.961
PV08_00622	PV08_05777	A0A0D2A5L7	A0A0D1ZSC6	Uncharacterized protein.	Uncharacterized protein.	0.880
PV08_00622	PV08_07511	A0A0D2A5L7	A0A0D1ZPI0	Uncharacterized protein.	Uncharacterized protein.	0.916
PV08_00622	PV08_10210	A0A0D2A5L7	A0A0D1Y7L8	Uncharacterized protein.	Uncharacterized protein.	0.765
PV08_00820	PV08_10210	A0A0D2BNY6	A0A0D1Y7L8	Chitin synthase 1.	Uncharacterized protein.	0.706
PV08_01267	PV08_00568	A0A0D2BQC3	A0A0D2BM57	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	RING-type domain-containing protein.	0.994
PV08_01267	PV08_00622	A0A0D2BQC3	A0A0D2A5L7	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Uncharacterized protein.	0.966
PV08_01267	PV08_01444	A0A0D2BQC3	A0A0D1YZX0	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	PRKCSH domain-containing protein.	0.966
PV08_01267	PV08_01680	A0A0D2BQC3	A0A0D1Z0H6	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Cell division control protein 48; Belongs to the AAA ATPase family.	0.987

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

14

PPI enrichment p-value:

1.33e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

10 of 151

1.27

1.95

1.33e-09

GO:0036211

Protein modification process

4 of 77

1.17

0.71

0.0172

GO:0000160

Phosphorelay signal transduction system

4 of 81

1.15

0.69

0.0187

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016772

Transferase activity, transferring phosphorus-containing groups

8 of 179

1.1

1.2

1.36e-05

GO:0000155

Phosphorelay sensor kinase activity

3 of 33

1.41

0.62

0.0499

GO:0016740

Transferase activity

9 of 486

0.72

0.59

0.00081

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

10 of 624

0.66

0.57

0.00013

GO:0016021

Integral component of membrane

9 of 771

0.52

0.39

0.0052

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3233

PAS domain, and Helix-turn-helix domain

5 of 19

1.87

2.64

1.05e-06

CL:3202

Signaling, and Diguanylate cyclase activity

9 of 114

1.35

2.15

1.47e-09

CL:3259

Mixed, incl. HPT domain superfamily, and Helix-turn-helix domain

3 of 6

2.15

2.01

0.00012

CL:3201

Signaling, and Diguanylate cyclase activity

10 of 158

1.25

1.9

1.09e-09

CL:3203

Signaling, and Diguanylate cyclase activity

7 of 106

1.27

1.59

2.22e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

11 of 403

0.89

1.01

2.36e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016020

Membrane

9 of 719

0.55

0.37

0.0179

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

5 of 57

1.4

1.44

0.00012

KW-0418

Kinase

6 of 86

1.3

1.4

4.96e-05

KW-0808

Transferase

7 of 354

0.75

0.56

0.0041

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000014

PAS domain

7 of 33

1.78

3.08

1.26e-08

IPR035965

PAS domain superfamily

7 of 34

1.77

3.06

1.26e-08

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

6 of 24

1.85

2.98

8.40e-08

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

6 of 27

1.8

2.84

1.17e-07

IPR005467

Histidine kinase domain

6 of 29

1.77

2.77

1.37e-07

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

7 of 29

1.84

3.6

4.76e-10

SM00387

Histidine kinase-like ATPases

7 of 39

1.71

3.14

1.51e-09

SM00091

PAS domain

7 of 39

1.71

3.14

1.51e-09

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

5 of 28

1.71

2.43

8.74e-07

SM00448

cheY-homologous receiver domain

6 of 51

1.52

2.22

3.12e-07

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (12%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About