PV08_10742 protein (Exophiala spinifera) - STRING interaction network

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:

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Score

PV08_10742

DNA primase; Belongs to the eukaryotic-type primase small subunit family. (526 aa)

Predicted Functional Partners:

PV08_04244

0.999

PV08_02032

0.998

PV08_00828

0.998

PV08_09462

0.984

PV08_01600

0.982

PV08_00287

0.975

PV08_08708

0.970

PV08_07020

0.966

PV08_06610

0.963

PV08_07653

0.954

Your Current Organism:

Exophiala spinifera

NCBI taxonomy Id: 91928
Other names: ATCC 18218, CBS 899.68, DUKE 3342, E. spinifera, NCMH 152, NCPF 2358, Phialophora spinifera, Rhinocladiella spinifera

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PV08_00287	PV08_00828	A0A0D2BL76	A0A0D2BMS9	AAA domain-containing protein.	DNA polymerase.	0.881
PV08_00287	PV08_01600	A0A0D2BL76	A0A0D1Z0D9	AAA domain-containing protein.	DNA polymerase.	0.924
PV08_00287	PV08_02032	A0A0D2BL76	A0A0D2A9L9	AAA domain-containing protein.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.914
PV08_00287	PV08_04244	A0A0D2BL76	A0A0D2BDP2	AAA domain-containing protein.	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family.	0.957
PV08_00287	PV08_06610	A0A0D2BL76	A0A0D2B548	AAA domain-containing protein.	DNA_pol_E_B domain-containing protein.	0.937
PV08_00287	PV08_07020	A0A0D2BL76	A0A0D2B5M4	AAA domain-containing protein.	DNA polymerase.	0.799
PV08_00287	PV08_07653	A0A0D2BL76	A0A0D2B7H0	AAA domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.856
PV08_00287	PV08_08708	A0A0D2BL76	A0A0D2B4D8	AAA domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.899
PV08_00287	PV08_09462	A0A0D2BL76	A0A0D1YB82	AAA domain-containing protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.890
PV08_00287	PV08_10742	A0A0D2BL76	A0A0D1ZER0	AAA domain-containing protein.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.975
PV08_00828	PV08_00287	A0A0D2BMS9	A0A0D2BL76	DNA polymerase.	AAA domain-containing protein.	0.881
PV08_00828	PV08_01600	A0A0D2BMS9	A0A0D1Z0D9	DNA polymerase.	DNA polymerase.	0.947
PV08_00828	PV08_02032	A0A0D2BMS9	A0A0D2A9L9	DNA polymerase.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.999
PV08_00828	PV08_04244	A0A0D2BMS9	A0A0D2BDP2	DNA polymerase.	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family.	0.999
PV08_00828	PV08_06610	A0A0D2BMS9	A0A0D2B548	DNA polymerase.	DNA_pol_E_B domain-containing protein.	0.982
PV08_00828	PV08_07020	A0A0D2BMS9	A0A0D2B5M4	DNA polymerase.	DNA polymerase.	0.525
PV08_00828	PV08_07653	A0A0D2BMS9	A0A0D2B7H0	DNA polymerase.	DNA helicase; Belongs to the MCM family.	0.986
PV08_00828	PV08_08708	A0A0D2BMS9	A0A0D2B4D8	DNA polymerase.	DNA helicase; Belongs to the MCM family.	0.980
PV08_00828	PV08_09462	A0A0D2BMS9	A0A0D1YB82	DNA polymerase.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.990
PV08_00828	PV08_10742	A0A0D2BMS9	A0A0D1ZER0	DNA polymerase.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.998

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Network Stats

number of nodes:

8

number of edges:

14

average node degree:

3.5

avg. local clustering coefficient:

0.917

expected number of edges:

11

PPI enrichment p-value:

0.206

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006811

Ion transport

8 of 221

1.31

1.75

4.92e-07

GO:0071702

Organic substance transport

6 of 168

1.3

1.42

4.63e-05

GO:0055085

Transmembrane transport

7 of 468

0.92

0.81

0.00047

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015420

ABC-type vitamin B12 transporter activity

5 of 21

2.13

3.15

2.79e-07

GO:0015288

Porin activity

5 of 65

1.64

2.02

9.92e-06

GO:0022857

Transmembrane transporter activity

8 of 492

0.96

0.97

2.30e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046930

Pore complex

5 of 20

2.15

3.83

6.91e-09

GO:0009279

Cell outer membrane

9 of 219

1.36

2.22

7.15e-10

GO:0016021

Integral component of membrane

8 of 1200

0.57

0.44

0.0025

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4162

Mixed, incl. TonB-dependent outer membrane protein, SusC/RagA, and SusD family

9 of 153

1.52

2.73

3.33e-10

CL:4163

Mixed, incl. TonB-dependent outer membrane protein, SusC/RagA, and SusD family

8 of 145

1.49

2.45

6.18e-09

CL:4437

Mixed, incl. Zinc-binding dehydrogenase, and Metallopeptidase, catalytic domain superfamily

3 of 8

2.32

1.96

0.00019

CL:4165

TonB-dependent outer membrane protein SusC/RagA, conserved site, and SusD family

5 of 118

1.38

1.34

0.00027

CL:4166

TonB-dependent outer membrane protein SusC/RagA, conserved site, and SusD family

4 of 113

1.3

0.92

0.0055

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

8 of 788

0.76

0.61

0.0011

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0019867

Outer membrane

9 of 228

1.35

2.11

2.56e-09

GOCC:0009279

Cell outer membrane

6 of 189

1.25

1.33

5.99e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1134

Transmembrane beta strand

8 of 83

1.73

3.53

5.37e-11

KW-0998

Cell outer membrane

8 of 100

1.65

3.22

1.10e-10

KW-0798

TonB box

8 of 100

1.65

3.22

1.10e-10

KW-0675

Receptor

8 of 122

1.57

2.89

2.52e-10

KW-0732

Signal

9 of 932

0.73

0.66

7.29e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00593

TonB dependent receptor

8 of 86

1.72

3.34

2.51e-10

PF07715

TonB-dependent Receptor Plug Domain

8 of 109

1.62

2.95

7.61e-10

PF13715

CarboxypepD_reg-like domain

8 of 110

1.61

2.94

7.61e-10

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023996

TonB-dependent outer membrane protein, SusC/RagA

8 of 63

1.85

3.89

5.82e-11

IPR023997

TonB-dependent outer membrane protein SusC/RagA, conserved site

7 of 59

1.82

3.42

1.64e-09

IPR000531

TonB-dependent receptor-like, beta-barrel

8 of 87

1.71

3.3

3.29e-10

IPR012910

TonB-dependent receptor, plug domain

8 of 112

1.6

2.86

1.50e-09

IPR037066

TonB-dependent receptor, plug domain superfamily

8 of 120

1.57

2.77

1.64e-09

(more ...)

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