PV08_08424 protein (Exophiala spinifera) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Coexpression

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Score

PV08_08424

Uncharacterized protein; Belongs to the complex I LYR family. (133 aa)

Predicted Functional Partners:

PV08_06689

0.954

PV08_02512

0.945

PV08_10279

0.924

PV08_05720

0.832

PV08_02229

0.832

PV08_02349

0.815

PV08_07719

0.811

PV08_08514

0.784

PV08_06459

0.784

PV08_04090

0.784

Your Current Organism:

Exophiala spinifera

NCBI taxonomy Id: 91928
Other names: ATCC 18218, CBS 899.68, DUKE 3342, E. spinifera, NCMH 152, NCPF 2358, Phialophora spinifera, Rhinocladiella spinifera

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PV08_02229	PV08_02349	A0A0D2CDN0	A0A0D1ZZF4	Haloacid dehalogenase, type II.	2Fe-2S ferredoxin-type domain-containing protein.	0.702
PV08_02229	PV08_04090	A0A0D2CDN0	A0A0D2BE79	Haloacid dehalogenase, type II.	Aminotran_5 domain-containing protein.	0.835
PV08_02229	PV08_06459	A0A0D2CDN0	A0A0D1ZUF6	Haloacid dehalogenase, type II.	Aminotran_5 domain-containing protein.	0.835
PV08_02229	PV08_06689	A0A0D2CDN0	A0A0D2B4Q7	Haloacid dehalogenase, type II.	Cysteine desulfurase, mitochondrial.	0.835
PV08_02229	PV08_08424	A0A0D2CDN0	A0A0D1ZK78	Haloacid dehalogenase, type II.	Uncharacterized protein; Belongs to the complex I LYR family.	0.832
PV08_02229	PV08_08514	A0A0D2CDN0	A0A0D1YE15	Haloacid dehalogenase, type II.	Aminotran_5 domain-containing protein.	0.835
PV08_02229	PV08_10279	A0A0D2CDN0	A0A0D2AX39	Haloacid dehalogenase, type II.	Iron-sulfur cluster assembly protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.942
PV08_02349	PV08_02229	A0A0D1ZZF4	A0A0D2CDN0	2Fe-2S ferredoxin-type domain-containing protein.	Haloacid dehalogenase, type II.	0.702
PV08_02349	PV08_02512	A0A0D1ZZF4	A0A0D2C3K7	2Fe-2S ferredoxin-type domain-containing protein.	Iron donor protein CyaY.	0.841
PV08_02349	PV08_04090	A0A0D1ZZF4	A0A0D2BE79	2Fe-2S ferredoxin-type domain-containing protein.	Aminotran_5 domain-containing protein.	0.830
PV08_02349	PV08_05720	A0A0D1ZZF4	A0A0D1YKX0	2Fe-2S ferredoxin-type domain-containing protein.	Haloacid dehalogenase, type II.	0.702
PV08_02349	PV08_06459	A0A0D1ZZF4	A0A0D1ZUF6	2Fe-2S ferredoxin-type domain-containing protein.	Aminotran_5 domain-containing protein.	0.830
PV08_02349	PV08_06689	A0A0D1ZZF4	A0A0D2B4Q7	2Fe-2S ferredoxin-type domain-containing protein.	Cysteine desulfurase, mitochondrial.	0.937
PV08_02349	PV08_07719	A0A0D1ZZF4	A0A0D1ZQ68	2Fe-2S ferredoxin-type domain-containing protein.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.831
PV08_02349	PV08_08424	A0A0D1ZZF4	A0A0D1ZK78	2Fe-2S ferredoxin-type domain-containing protein.	Uncharacterized protein; Belongs to the complex I LYR family.	0.815
PV08_02349	PV08_08514	A0A0D1ZZF4	A0A0D1YE15	2Fe-2S ferredoxin-type domain-containing protein.	Aminotran_5 domain-containing protein.	0.830
PV08_02349	PV08_10279	A0A0D1ZZF4	A0A0D2AX39	2Fe-2S ferredoxin-type domain-containing protein.	Iron-sulfur cluster assembly protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.946
PV08_02512	PV08_02349	A0A0D2C3K7	A0A0D1ZZF4	Iron donor protein CyaY.	2Fe-2S ferredoxin-type domain-containing protein.	0.841
PV08_02512	PV08_04090	A0A0D2C3K7	A0A0D2BE79	Iron donor protein CyaY.	Aminotran_5 domain-containing protein.	0.835
PV08_02512	PV08_06459	A0A0D2C3K7	A0A0D1ZUF6	Iron donor protein CyaY.	Aminotran_5 domain-containing protein.	0.835

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.908

expected number of edges:

11

PPI enrichment p-value:

0.000808

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046474

Glycerophospholipid biosynthetic process

3 of 157

2.22

1.8

0.0021

GO:0015914

Phospholipid transport

2 of 43

2.61

1.55

0.0065

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030572

Phosphatidyltransferase activity

2 of 2

3.94

2.79

0.00014

GO:0008444

CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity

2 of 2

3.94

2.79

0.00014

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005740

Mitochondrial envelope

4 of 439

1.9

2.63

2.15e-05

GO:0005758

Mitochondrial intermembrane space

2 of 34

2.71

2.09

0.0011

GO:0031967

Organelle envelope

5 of 1325

1.52

1.99

2.15e-05

GO:0005739

Mitochondrion

5 of 1529

1.46

1.87

2.15e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:50852

PRELI-like family, and Phosphatidate cytidylyltransferase, mitochondrial

2 of 5

3.54

2.56

0.00029

CL:32333

Mixed, incl. Phospholipid catabolic process, and CDP-alcohol phosphatidyltransferase activity

3 of 73

2.56

2.47

0.00027

CL:32429

Mixed, incl. CDP-alcohol phosphatidyltransferase, and Tafazzin

2 of 11

3.2

2.35

0.00054

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00564

Glycerophospholipid metabolism

3 of 311

1.93

1.98

0.00056

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1482925

Acyl chain remodelling of PG

2 of 4

3.64

2.81

0.00013

MAP-6803204

TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

2 of 9

3.29

2.66

0.00020

MAP-1483206

Glycerophospholipid biosynthesis

3 of 157

2.22

2.42

0.00020

MAP-1483257

Phospholipid metabolism

3 of 283

1.97

2.01

0.00056

MAP-5633008

TP53 Regulates Transcription of Cell Death Genes

2 of 63

2.44

1.71

0.0035

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005739

Mitochondrion

5 of 1320

1.52

1.94

3.38e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0594

Phospholipid biosynthesis

3 of 15

3.24

4.72

2.38e-07

KW-0999

Mitochondrion inner membrane

2 of 60

2.46

2.0

0.0013

KW-0809

Transit peptide

3 of 453

1.76

1.75

0.00090

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01066

CDP-alcohol phosphatidyltransferase

2 of 5

3.54

2.42

0.00045

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR043130

CDP-alcohol phosphatidyltransferase, transmembrane domain

2 of 5

3.54

2.09

0.0013

IPR000462

CDP-alcohol phosphatidyltransferase

2 of 5

3.54

2.09

0.0013

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