PV08_08140 protein (Exophiala spinifera) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

Your Input:

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Coexpression

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[Homology]

Score

PV08_08140

Amidohydro-rel domain-containing protein. (919 aa)

Predicted Functional Partners:

PV08_08490

0.808

PV08_00855

0.808

PV08_04192

0.765

PV08_09135

0.765

PV08_01237

0.765

PV08_05916

0.756

PV08_12046

0.756

PV08_12009

0.756

PV08_12066

0.756

PV08_00624

0.746

Your Current Organism:

Exophiala spinifera

NCBI taxonomy Id: 91928
Other names: ATCC 18218, CBS 899.68, DUKE 3342, E. spinifera, NCMH 152, NCPF 2358, Phialophora spinifera, Rhinocladiella spinifera

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PV08_00624	PV08_00855	A0A0D2C935	A0A0D2BP26	Uncharacterized protein.	Dihydroorotate dehydrogenase (Fumarate).	0.980
PV08_00624	PV08_01237	A0A0D2C935	A0A0D2BQ86	Uncharacterized protein.	Carbamoyl-phosphate synthase arginine-specific small chain.	0.857
PV08_00624	PV08_04192	A0A0D2C935	A0A0D1YPD1	Uncharacterized protein.	Carbamoyl-phosphate synthase arginine-specific large chain.	0.857
PV08_00624	PV08_05916	A0A0D2C935	A0A0D1YLF5	Uncharacterized protein.	Tryptophan synthase.	0.663
PV08_00624	PV08_08140	A0A0D2C935	A0A0D2B233	Uncharacterized protein.	Amidohydro-rel domain-containing protein.	0.746
PV08_00624	PV08_08490	A0A0D2C935	A0A0D1ZKE2	Uncharacterized protein.	Dihydroorotate dehydrogenase (fumarate); Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.	0.980
PV08_00624	PV08_09135	A0A0D2C935	A0A0D1ZFU6	Uncharacterized protein.	Protein pyrABCN.	0.857
PV08_00624	PV08_12009	A0A0D2C935	A0A0D2AT76	Uncharacterized protein.	Tryptophan synthase.	0.663
PV08_00624	PV08_12046	A0A0D2C935	A0A0D2ASL0	Uncharacterized protein.	Tryptophan synthase.	0.663
PV08_00624	PV08_12066	A0A0D2C935	A0A0D2BE61	Uncharacterized protein.	Tryptophan synthase.	0.663
PV08_00855	PV08_00624	A0A0D2BP26	A0A0D2C935	Dihydroorotate dehydrogenase (Fumarate).	Uncharacterized protein.	0.980
PV08_00855	PV08_01237	A0A0D2BP26	A0A0D2BQ86	Dihydroorotate dehydrogenase (Fumarate).	Carbamoyl-phosphate synthase arginine-specific small chain.	0.902
PV08_00855	PV08_04192	A0A0D2BP26	A0A0D1YPD1	Dihydroorotate dehydrogenase (Fumarate).	Carbamoyl-phosphate synthase arginine-specific large chain.	0.930
PV08_00855	PV08_08140	A0A0D2BP26	A0A0D2B233	Dihydroorotate dehydrogenase (Fumarate).	Amidohydro-rel domain-containing protein.	0.808
PV08_00855	PV08_08490	A0A0D2BP26	A0A0D1ZKE2	Dihydroorotate dehydrogenase (Fumarate).	Dihydroorotate dehydrogenase (fumarate); Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.	0.734
PV08_00855	PV08_09135	A0A0D2BP26	A0A0D1ZFU6	Dihydroorotate dehydrogenase (Fumarate).	Protein pyrABCN.	0.930
PV08_01237	PV08_00624	A0A0D2BQ86	A0A0D2C935	Carbamoyl-phosphate synthase arginine-specific small chain.	Uncharacterized protein.	0.857
PV08_01237	PV08_00855	A0A0D2BQ86	A0A0D2BP26	Carbamoyl-phosphate synthase arginine-specific small chain.	Dihydroorotate dehydrogenase (Fumarate).	0.902
PV08_01237	PV08_04192	A0A0D2BQ86	A0A0D1YPD1	Carbamoyl-phosphate synthase arginine-specific small chain.	Carbamoyl-phosphate synthase arginine-specific large chain.	0.997
PV08_01237	PV08_05916	A0A0D2BQ86	A0A0D1YLF5	Carbamoyl-phosphate synthase arginine-specific small chain.	Tryptophan synthase.	0.604

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Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.816

expected number of edges:

17

PPI enrichment p-value:

0.0141

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

5 of 19

1.94

2.47

4.76e-06

GO:0034654

Nucleobase-containing compound biosynthetic process

6 of 141

1.15

1.04

0.00051

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

4 of 5

2.42

2.82

4.12e-06

GO:0016772

Transferase activity, transferring phosphorus-containing groups

6 of 175

1.05

0.9

0.00095

GO:0003677

DNA binding

6 of 324

0.79

0.51

0.0172

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

4 of 7

2.28

2.89

2.05e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:302

RNA polymerase

5 of 5

2.52

4.01

1.81e-08

CL:3370

Cyclic nucleotide-binding domain

3 of 6

2.22

1.74

0.00048

CL:3236

Signal transduction, and GGDEF domain

4 of 78

1.23

0.85

0.0071

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pla03020

RNA polymerase

4 of 4

2.52

3.38

3.65e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9635486

Infection with Mycobacterium tuberculosis

4 of 81

1.21

0.97

0.0022

MAP-5663205

Infectious disease

4 of 83

1.2

0.96

0.0022

MAP-1643685

Disease

4 of 91

1.16

0.93

0.0022

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

5 of 43

1.58

1.78

4.25e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

4 of 6

2.34

2.93

2.02e-06

KW-0548

Nucleotidyltransferase

4 of 33

1.6

1.58

0.00020

KW-0804

Transcription

6 of 130

1.18

1.2

0.00010

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00100

Cyclic nucleotide-monophosphate binding domain

2 of 6

2.04

0.87

0.0234

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