PV08_05320 protein (Exophiala spinifera) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

PV08_05320

Uncharacterized protein. (356 aa)

Predicted Functional Partners:

PV08_06741

0.538

PV08_00879

0.536

PV08_03145

0.531

PV08_03447

0.527

PV08_06235

0.523

PV08_04787

0.522

RPS1

0.521

PV08_05298

0.521

PV08_03935

0.507

PV08_04977

0.504

Your Current Organism:

Exophiala spinifera

NCBI taxonomy Id: 91928
Other names: ATCC 18218, CBS 899.68, DUKE 3342, E. spinifera, NCMH 152, NCPF 2358, Phialophora spinifera, Rhinocladiella spinifera

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PV08_00879	PV08_03447	A0A0D2C9P3	A0A0D2C6F7	Uncharacterized protein.	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family.	0.951
PV08_00879	PV08_03935	A0A0D2C9P3	A0A0D1YNQ8	Uncharacterized protein.	Uncharacterized protein.	0.999
PV08_00879	PV08_04787	A0A0D2C9P3	A0A0D1ZY75	Uncharacterized protein.	Pre-rRNA-processing protein PNO1.	0.999
PV08_00879	PV08_04977	A0A0D2C9P3	A0A0D1ZYN6	Uncharacterized protein.	40S ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family.	0.999
PV08_00879	PV08_05298	A0A0D2C9P3	A0A0D2B8I0	Uncharacterized protein.	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family.	0.998
PV08_00879	PV08_05320	A0A0D2C9P3	A0A0D2B9E7	Uncharacterized protein.	Uncharacterized protein.	0.536
PV08_00879	PV08_06235	A0A0D2C9P3	A0A0D2BY05	Uncharacterized protein.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.999
PV08_00879	PV08_06741	A0A0D2C9P3	A0A0D2B5K1	Uncharacterized protein.	Bms1-type G domain-containing protein.	0.999
PV08_00879	RPS1	A0A0D2C9P3	A0A0D1YPV2	Uncharacterized protein.	40S ribosomal protein S1; Belongs to the eukaryotic ribosomal protein eS1 family.	0.981
PV08_03145	PV08_05320	A0A0D1YUC3	A0A0D2B9E7	Uncharacterized protein.	Uncharacterized protein.	0.531
PV08_03447	PV08_00879	A0A0D2C6F7	A0A0D2C9P3	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family.	Uncharacterized protein.	0.951
PV08_03447	PV08_03935	A0A0D2C6F7	A0A0D1YNQ8	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family.	Uncharacterized protein.	0.898
PV08_03447	PV08_04787	A0A0D2C6F7	A0A0D1ZY75	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family.	Pre-rRNA-processing protein PNO1.	0.910
PV08_03447	PV08_04977	A0A0D2C6F7	A0A0D1ZYN6	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family.	40S ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family.	0.999
PV08_03447	PV08_05298	A0A0D2C6F7	A0A0D2B8I0	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family.	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family.	0.999
PV08_03447	PV08_05320	A0A0D2C6F7	A0A0D2B9E7	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family.	Uncharacterized protein.	0.527
PV08_03447	PV08_06235	A0A0D2C6F7	A0A0D2BY05	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.999
PV08_03447	PV08_06741	A0A0D2C6F7	A0A0D2B5K1	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family.	Bms1-type G domain-containing protein.	0.891
PV08_03447	RPS1	A0A0D2C6F7	A0A0D1YPV2	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family.	40S ribosomal protein S1; Belongs to the eukaryotic ribosomal protein eS1 family.	0.999
PV08_03935	PV08_00879	A0A0D1YNQ8	A0A0D2C9P3	Uncharacterized protein.	Uncharacterized protein.	0.999

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Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.902

expected number of edges:

10

PPI enrichment p-value:

2.61e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0048066

Developmental pigmentation

7 of 26

2.91

7.86

1.18e-15

GO:0050931

Pigment cell differentiation

6 of 21

2.94

6.7

2.73e-13

GO:0032438

Melanosome organization

5 of 16

2.98

5.54

5.26e-11

GO:0043485

Endosome to pigment granule transport

3 of 9

3.01

3.04

2.81e-06

GO:0030318

Melanocyte differentiation

3 of 13

2.85

2.89

4.84e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030742

GTP-dependent protein binding

4 of 23

2.72

3.5

2.97e-07

GO:0035651

AP-3 adaptor complex binding

3 of 3

3.48

3.41

7.11e-07

GO:0035650

AP-1 adaptor complex binding

3 of 5

3.26

3.25

1.33e-06

GO:0005093

Rab GDP-dissociation inhibitor activity

2 of 2

3.48

1.89

0.00040

GO:0003924

GTPase activity

4 of 342

1.55

1.21

0.0019

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031082

BLOC complex

4 of 15

2.91

4.07

3.05e-08

GO:0044233

Mitochondria-associated endoplasmic reticulum membrane

3 of 14

2.81

2.82

6.59e-06

GO:0033162

Melanosome membrane

3 of 19

2.68

2.77

7.30e-06

GO:0030670

Phagocytic vesicle membrane

3 of 18

2.71

2.77

7.30e-06

GO:0042470

Melanosome

4 of 84

2.16

2.59

6.59e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:42628

Mixed, incl. BLOC complex, and AP-3 adaptor complex binding

9 of 20

3.14

12.03

1.85e-23

CL:42629

Mixed, incl. BLOC-2 complex, and AP-3 adaptor complex binding

7 of 13

3.21

9.42

3.35e-18

CL:42630

BLOC-2 complex, and AP-3 adaptor complex binding

6 of 8

3.36

8.28

6.97e-16

CL:42655

Protein phosphatase 2C, and Ras-related protein Rab29/Rab38/Rab32

2 of 6

3.01

1.46

0.0023

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8876198

RAB GEFs exchange GTP for GDP on RABs

7 of 133

2.2

5.01

9.97e-12

MAP-9007101

Rab regulation of trafficking

7 of 178

2.08

4.53

3.62e-11

MAP-8873719

RAB geranylgeranylation

4 of 70

2.24

2.8

2.94e-06

MAP-199991

Membrane Trafficking

7 of 977

1.34

1.69

2.94e-06

MAP-5653656

Vesicle-mediated transport

7 of 1087

1.29

1.59

3.66e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031082

BLOC complex

7 of 16

3.12

9.04

1.33e-17

GOCC:0031085

BLOC-3 complex

5 of 5

3.48

6.93

2.56e-13

GOCC:0033162

Melanosome membrane

3 of 29

2.5

2.3

5.04e-05

GOCC:0045335

Phagocytic vesicle

3 of 38

2.38

2.22

6.17e-05

GOCC:0031084

BLOC-2 complex

2 of 4

3.18

2.04

0.00021

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0343

GTPase activation

2 of 30

2.31

0.99

0.0150

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00996

GDP dissociation inhibitor

2 of 3

3.31

1.46

0.0024

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030697

Ras-related protein Rab29/Rab38/Rab32

3 of 3

3.48

3.01

3.79e-06

IPR001806

Small GTPase

4 of 138

1.95

1.7

0.00036

IPR000806

Rab GDI protein

2 of 2

3.48

1.59

0.0014

IPR018203

GDP dissociation inhibitor

2 of 3

3.31

1.53

0.0018

IPR005225

Small GTP-binding protein domain

3 of 154

1.77

0.84

0.0233

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00175

Rab subfamily of small GTPases

3 of 51

2.25

1.74

0.00050

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