PV08_10188 protein (Exophiala spinifera) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PV08_10188

HUN domain-containing protein. (598 aa)

Predicted Functional Partners:

PV08_08174

0.970

PV08_11169

0.938

PV08_11342

0.517

PV08_07334

0.511

PV08_07426

0.500

PV08_02349

0.500

PV08_03048

0.474

PV08_04477

0.468

PV08_10352

0.468

PV08_04354

0.468

Your Current Organism:

Exophiala spinifera

NCBI taxonomy Id: 91928
Other names: ATCC 18218, CBS 899.68, DUKE 3342, E. spinifera, NCMH 152, NCPF 2358, Phialophora spinifera, Rhinocladiella spinifera

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PV08_02349	PV08_10188	A0A0D1ZZF4	A0A0D2BHN7	2Fe-2S ferredoxin-type domain-containing protein.	HUN domain-containing protein.	0.500
PV08_03048	PV08_08174	A0A0D2C583	A0A0D1ZJL1	Rtt106 domain-containing protein.	Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.	0.574
PV08_03048	PV08_10188	A0A0D2C583	A0A0D2BHN7	Rtt106 domain-containing protein.	HUN domain-containing protein.	0.474
PV08_03048	PV08_11169	A0A0D2C583	A0A0D2ATY8	Rtt106 domain-containing protein.	Histone chaperone; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.	0.721
PV08_04354	PV08_04477	A0A0D2BDX4	A0A0D1YPY1	CRAL-TRIO domain-containing protein.	CRAL-TRIO domain-containing protein.	0.577
PV08_04354	PV08_10188	A0A0D2BDX4	A0A0D2BHN7	CRAL-TRIO domain-containing protein.	HUN domain-containing protein.	0.468
PV08_04477	PV08_04354	A0A0D1YPY1	A0A0D2BDX4	CRAL-TRIO domain-containing protein.	CRAL-TRIO domain-containing protein.	0.577
PV08_04477	PV08_10188	A0A0D1YPY1	A0A0D2BHN7	CRAL-TRIO domain-containing protein.	HUN domain-containing protein.	0.468
PV08_04477	PV08_10352	A0A0D1YPY1	A0A0D2AWI6	CRAL-TRIO domain-containing protein.	CRAL-TRIO domain-containing protein.	0.672
PV08_07334	PV08_10188	A0A0D2B7C3	A0A0D2BHN7	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	HUN domain-containing protein.	0.511
PV08_07426	PV08_10188	A0A0D1ZPA8	A0A0D2BHN7	Uncharacterized protein.	HUN domain-containing protein.	0.500
PV08_08174	PV08_03048	A0A0D1ZJL1	A0A0D2C583	Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.	Rtt106 domain-containing protein.	0.574
PV08_08174	PV08_10188	A0A0D1ZJL1	A0A0D2BHN7	Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.	HUN domain-containing protein.	0.970
PV08_08174	PV08_11169	A0A0D1ZJL1	A0A0D2ATY8	Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.	Histone chaperone; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.	0.999
PV08_08174	PV08_11342	A0A0D1ZJL1	A0A0D2AV82	Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.	Uncharacterized protein.	0.565
PV08_10188	PV08_02349	A0A0D2BHN7	A0A0D1ZZF4	HUN domain-containing protein.	2Fe-2S ferredoxin-type domain-containing protein.	0.500
PV08_10188	PV08_03048	A0A0D2BHN7	A0A0D2C583	HUN domain-containing protein.	Rtt106 domain-containing protein.	0.474
PV08_10188	PV08_04354	A0A0D2BHN7	A0A0D2BDX4	HUN domain-containing protein.	CRAL-TRIO domain-containing protein.	0.468
PV08_10188	PV08_04477	A0A0D2BHN7	A0A0D1YPY1	HUN domain-containing protein.	CRAL-TRIO domain-containing protein.	0.468
PV08_10188	PV08_07334	A0A0D2BHN7	A0A0D2B7C3	HUN domain-containing protein.	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.511

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.885

expected number of edges:

11

PPI enrichment p-value:

0.000195

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001732

Formation of cytoplasmic translation initiation complex

10 of 16

2.95

12.23

1.43e-24

GO:0006446

Regulation of translational initiation

3 of 19

2.35

2.27

4.70e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003743

Translation initiation factor activity

11 of 44

2.55

11.02

6.93e-25

GO:0031369

Translation initiation factor binding

2 of 20

2.15

0.89

0.0217

GO:0003723

RNA binding

5 of 678

1.02

0.65

0.0139

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033290

Eukaryotic 48S preinitiation complex

11 of 15

3.02

14.64

2.50e-29

GO:0005852

Eukaryotic translation initiation factor 3 complex

10 of 14

3.0

13.14

3.29e-26

GO:0016282

Eukaryotic 43S preinitiation complex

10 of 18

2.9

12.54

1.65e-25

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7924

Translation preinitiation complex

11 of 20

2.89

13.62

6.42e-28

CL:7926

Eukaryotic translation initiation factor 3 complex

10 of 12

3.07

13.34

2.54e-26

CL:7938

Eukaryotic translation initiation factor 3 complex

5 of 6

3.07

5.93

1.15e-11

CL:7927

Eukaryotic translation initiation factor 3 complex

5 of 6

3.07

5.93

1.15e-11

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03013

RNA transport

9 of 180

1.85

4.61

4.04e-14

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72695

Formation of the ternary complex, and subsequently, the 43S complex

11 of 49

2.5

10.67

1.46e-24

MAP-72649

Translation initiation complex formation

11 of 56

2.44

10.29

2.74e-24

MAP-72702

Ribosomal scanning and start codon recognition

11 of 58

2.43

10.21

2.74e-24

MAP-72662

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

11 of 59

2.42

10.17

2.74e-24

MAP-156827

L13a-mediated translational silencing of Ceruloplasmin expression

11 of 102

2.18

8.15

4.95e-22

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005852

Eukaryotic translation initiation factor 3 complex

9 of 13

2.99

11.24

2.49e-22

GOCC:0071541

Eukaryotic translation initiation factor 3 complex, eIF3m

3 of 4

3.03

2.86

6.15e-06

GOCC:0071540

Eukaryotic translation initiation factor 3 complex, eIF3e

2 of 2

3.15

1.74

0.00073

GOCC:0043614

multi-eIF complex

2 of 2

3.15

1.74

0.00073

GOCC:0070993

Translation preinitiation complex

2 of 4

2.85

1.59

0.0013

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0396

Initiation factor

8 of 19

2.77

9.11

1.14e-18

KW-0963

Cytoplasm

8 of 161

1.85

4.21

2.32e-12

KW-0694

RNA-binding

3 of 191

1.35

0.76

0.0194

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000717

Proteasome component (PCI) domain

4 of 18

2.5

2.87

3.75e-06

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00088

Motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

3 of 13

2.51

2.21

7.67e-05

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (26%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About