Topbp1-2 protein (Trichinella sp. T6) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

Topbp1-2

DNA topoisomerase 2-binding protein 1. (1305 aa)

Predicted Functional Partners:

CDC45

0.953

Gins4

0.946

ATR

0.936

GINS3

0.936

Rad9a

0.932

mcm5

0.931

GINS1

0.929

zmcm3

0.927

Gins2

0.925

Pole2

0.921

Your Current Organism:

Trichinella sp. T6

NCBI taxonomy Id: 92179
Other names: T. sp. T6, Trichinella T6

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATR	CDC45	A0A0V0W4R5	A0A0V0WI25	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Cell division control protein 45-like protein.	0.919
ATR	Rad9a	A0A0V0W4R5	A0A0V0X0P6	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.989
ATR	Topbp1-2	A0A0V0W4R5	A0A0V0W775	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	DNA topoisomerase 2-binding protein 1.	0.936
ATR	mcm5	A0A0V0W4R5	A0A0V0WZF1	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	DNA helicase; Belongs to the MCM family.	0.550
ATR	zmcm3	A0A0V0W4R5	A0A0V0WB62	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	DNA helicase; Belongs to the MCM family.	0.585
CDC45	ATR	A0A0V0WI25	A0A0V0W4R5	Cell division control protein 45-like protein.	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	0.919
CDC45	GINS1	A0A0V0WI25	A0A0V0WXL8	Cell division control protein 45-like protein.	DNA replication complex GINS protein PSF1.	0.999
CDC45	GINS3	A0A0V0WI25	A0A0V0WYV9	Cell division control protein 45-like protein.	DNA replication complex GINS protein PSF3.	0.999
CDC45	Gins2	A0A0V0WI25	A0A0V0WH99	Cell division control protein 45-like protein.	DNA replication complex GINS protein PSF2.	0.999
CDC45	Gins4	A0A0V0WI25	A0A0V0WDJ4	Cell division control protein 45-like protein.	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family.	0.999
CDC45	Pole2	A0A0V0WI25	A0A0V0X171	Cell division control protein 45-like protein.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.994
CDC45	Rad9a	A0A0V0WI25	A0A0V0X0P6	Cell division control protein 45-like protein.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.747
CDC45	Topbp1-2	A0A0V0WI25	A0A0V0W775	Cell division control protein 45-like protein.	DNA topoisomerase 2-binding protein 1.	0.953
CDC45	mcm5	A0A0V0WI25	A0A0V0WZF1	Cell division control protein 45-like protein.	DNA helicase; Belongs to the MCM family.	0.999
CDC45	zmcm3	A0A0V0WI25	A0A0V0WB62	Cell division control protein 45-like protein.	DNA helicase; Belongs to the MCM family.	0.998
GINS1	CDC45	A0A0V0WXL8	A0A0V0WI25	DNA replication complex GINS protein PSF1.	Cell division control protein 45-like protein.	0.999
GINS1	GINS3	A0A0V0WXL8	A0A0V0WYV9	DNA replication complex GINS protein PSF1.	DNA replication complex GINS protein PSF3.	0.999
GINS1	Gins2	A0A0V0WXL8	A0A0V0WH99	DNA replication complex GINS protein PSF1.	DNA replication complex GINS protein PSF2.	0.999
GINS1	Gins4	A0A0V0WXL8	A0A0V0WDJ4	DNA replication complex GINS protein PSF1.	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family.	0.999
GINS1	Pole2	A0A0V0WXL8	A0A0V0X171	DNA replication complex GINS protein PSF1.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.970